Double/Triple Combinations of AN2025, AN0025 and Atezolizumab in Advanced Solid Tumors

  • STATUS
    Recruiting
  • participants needed
    63
  • sponsor
    Adlai Nortye Biopharma Co., Ltd.
Updated on 9 December 2022

Summary

This is an open-label, multicenter, Phase 1a study to evaluate the safety, tolerability, PK and preliminary efficacy of AN2025 and AN0025 in double or triple combination treatments with Atezolizumab in patients with locally advanced/metastatic tumors.

Description

This is an open-label, multicenter, Phase 1a study to evaluate the safety, tolerability, PK and preliminary efficacy of AN2025 and AN0025 in double or triple combination treatments with Atezolizumab in patients with locally advanced/metastatic tumors. This study consists of three DLT Observation Periods I, II and III. Observations I and II are double combination treatments, which will be conducted in parallel, whereas Observation III (the triple combination treatment) will be initiated only after a thorough review of the safety data from Observations I and II. In all three Observation Periods, a "6 + 3 design" will be utilized for dose finding with dose escalation and de-escalation.

Details
Condition Locally Advanced Solid Tumor
Treatment AN0025, Atezolizumab 1200 MG in 20 ML Injection, AN2025
Clinical Study IdentifierNCT04975958
SponsorAdlai Nortye Biopharma Co., Ltd.
Last Modified on9 December 2022

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