PurIST Classification-Guided Adaptive Neoadjuvant Chemotherapy by RNA Expression Profiling of EUS Aspiration Samples (PANCREAS)

  • End date
    Jun 11, 2025
  • participants needed
  • sponsor
    Medical College of Wisconsin
Updated on 4 October 2022
cancer chemotherapy


This is an open-label, phase II study in patients with resectable and borderline resectable pancreatic cancer.


The study intervention involves molecular profiling Purity Independent Subtyping of Tumors (PurIST) subtyping of pretreatment Endoscopic Ultrasound Fine Needle Aspiration (EUS/FNA) samples to determine pancreatic cancer subtype. Neoadjuvant therapy is directed based on the molecular subtype (classical vs. basal). Patients with classical subtype will receive a standard chemotherapy (mFOLFIRINOX) and patients with basal subtype will receive an alternative standard therapy (gemcitabine/nab-paclitaxel).

Condition Pancreatic Cancer
Treatment Chemoradiation, mFOLFIRINOX Treatment Regimen, Gemcitabine/Nab-paclitaxel Treatment Regimen
Clinical Study IdentifierNCT04683315
SponsorMedical College of Wisconsin
Last Modified on4 October 2022


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