Total Post-thyroidectomy Hypocalcemia After Preoperative Cholecalciferol Supplementation (CAVITHY)

  • End date
    Mar 16, 2025
  • participants needed
  • sponsor
    Centre Hospitalier René Dubos
Updated on 4 October 2022


This prospective study evalue the inflence of pre operative vit D3 administration on post operative hypocalcemia in patients undergoing Total thyroidectomy


Thyroidectomy is a frequent procedure. This surgery is well known but not devoid of risks. The most common postoperative complication is transitory hypocalcemia. Some studies have reported that preoperative vitamin D deficiency (VDD) is a risk factor for hypocalcemia after total thyroidectomy (TT) in patients with non toxic multinodular goiter or graves's disease. Although the association between VVD and postoperative hypocalcemia in thyroid cancer patients undergoing TT plus central compartment neck dissection (CCND) remains unclear. This prospective study evalue the inflence of pre operative vit D3 administration on post operative hypocalcemia in patients undergoing TT.

Condition Hypocalcemia
Treatment Vitamin D
Clinical Study IdentifierNCT04775381
SponsorCentre Hospitalier René Dubos
Last Modified on4 October 2022


Yes No Not Sure

Inclusion Criteria

Patient ≥ 18 years old
Patient shall be operated on for a total thyroidectomy in one time for any indication
Written informed consent (IC) obtained
Patients with affiliation to the social security system

Exclusion Criteria

• Medical history of : Thyroid or parathyroid surgery Hyperparathyroidism Granulomatosis
Hypocalcemia, hypercalcemia/ hypercalciuria, or symptom of Hypocalcemia
hypercalcemia/ hypercalciuria, not due to thyroid pathologies
Chronic kidney disease grade ≥4
Severe liver failure
OHD supplementation within last 3 months before surgery
Malabsorption syndrome
Known hypersensitivity to vitamin D
Medical history of calcic lithiasis
Pregnant women
Vulnerable populations (guardianship or trusteeship)
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