The SINgapore GERiatric Intervention Study to Reduce Cognitive Decline and Physical Frailty (SINGER) Study (SINGER)

  • STATUS
    Recruiting
  • End date
    Jan 31, 2026
  • participants needed
    1200
  • sponsor
    National University, Singapore
Updated on 24 January 2022
dementia
cognitive decline
Accepts healthy volunteers

Summary

A study in Finland found that a multidomain intervention of physical activity, nutritional guidance, cognitive training, social activities and management of vascular risk factors slowed cognitive decline in healthy older adults at increased risk of cognitive decline. A 6-month pilot study was initiated in Singapore, which demonstrated the cultural feasibility and practicality of the FINGER interventions and a set of locally adapted interventions in an Asian population. The SINGER study is a 2-year randomized controlled trial that aims to test the efficacy and safety of these lifestyle changes, including diet and cardiovascular risk factor management, cognitive and physical exercises, in delaying cognitive decline in older adults at risk of dementia.

Description

Results from a population-based 2-year clinical trial, the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER), demonstrated that a multidomain intervention of physical activity, nutritional guidance, cognitive training, social activities and management of vascular risk factors slowed cognitive decline in healthy older adults at increased risk of cognitive decline. Currently, no pharmacological treatment options that can rival these effects. Thus, there is an urgent need to test the generalizability, adaptability, and sustainability of these findings in Singaporean populations. A 6-month pilot study was initiated in Singapore, which demonstrated the cultural feasibility and practicality of the FINGER interventions and a set of locally adapted interventions in an Asian population. Hence, the next step was to conduct a larger scale SINGER trial to determine the efficacy of these interventions in Singapore. If the interventions are found to be effective and safe with high applicability and scalability, the study will provide important clinical and public health implications to a rapidly increasing ageing population.

Details
Condition Cognitive Impairment, Alzheimer Disease, Vascular Cognitive Impairment, Dementia, Brain Diseases, Central Nervous System Diseases, Nervous System Diseases, Neurocognitive Disorders, Mental Disorders, Cognition Disorder
Treatment Structured Lifestyle Intervention, Self-Guided Intervention
Clinical Study IdentifierNCT05007353
SponsorNational University, Singapore
Last Modified on24 January 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Age 60-77 years
Able to understand English/Chinese
Risk of dementia: Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) dementia risk score >6 indicating the presence of modifiable risk factors Modifiable lifestyle factors (fulfilling at least one of the following LIBRA index for diet, cognitive activity, physical activity)
Cognitive performance at the mean level or slightly lower than expected for age (MoCA 18, 27)
No plans to travel outside of Singapore for an extended period of time over the course of the study
Free of physical disabilities that preclude participation in the study
Willing to complete all study-related activities for 24 months
Willing to be randomized to either lifestyle intervention group

Exclusion Criteria

malignant diseases
dementia
substantial cognitive decline (MoCA<18)
major depression
symptomatic cardiovascular disease
revascularisation within 1 year
severe loss of vision, hearing or communicative ability
other conditions inhibiting from safe engagement in the prescribed intervention and other conditions preventing cooperation, as judged by the study physician
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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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