A Study of MRG004A in Patients With Tissue Factor Positive Advanced or Metastatic Solid Tumors

  • STATUS
    Recruiting
  • End date
    Jun 7, 2025
  • participants needed
    181
  • sponsor
    Shanghai Miracogen Inc.
Updated on 7 June 2022

Summary

The objective of this study is to evaluate the safety, efficacy, pharmacokinetics, and immunogenicity of MRG004A in patients with Tissue Factor positive advanced or metastatic solid tumors.

Description

This study consists of two parts. Part A is a dose escalation study to determine the maximum tolerated dose (MTD) and recommended phase II dose (RP2D) of MRG004A. Part B is a disease specific multi-cohort dose expansion study to further assess the efficacy and safety of MRG004A at confirmed RP2D.

Details
Condition Advanced or Metastatic Solid Tumors
Treatment MRG004A
Clinical Study IdentifierNCT04843709
SponsorShanghai Miracogen Inc.
Last Modified on7 June 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Understands and provides written informed consent and willing to follow the requirements specified in protocol
Age ≥18 years
Life expectancy ≥6 months
For Part B patients, documented Tissue Factor (TF) presence in tumor biopsy specimens obtained from archival or re-biopsy specimens by immunohistochemistry (IHC) protein expression
Must have histologically or cytologically confirmed unresectable or metastatic cancer with documented disease progression during prior therapy, or relapse or progression following approved standard therapy for their tumor types- Part A and Part B
Part B: Patients who have documented progression during or relapse following standard therapy, no further treatment options that are known to improve survival, and participation in a clinical trial is a reasonable therapeutic option
Patients must have measurable disease per RECIST v1.1
ECOG performance status of 0 or 1
Acceptable bone marrow, hepatic, cardiac, renal, and coagulation function
A negative serum pregnancy test if female and aged between 18-55 years old
Patients, both females and males, of reproductive potential must agree to use adequate contraception during and for 180 days after the last infusion of MRG004A

Exclusion Criteria

Archival or biopsy tumor shows TF IHC membrane or cytosolic score of zero, no TF-positive expression or no TF-positive staining in Part B patients
Toxicities (except alopecia & fatigue) due to prior antitumor therapy are greater than CTCAE v5.0 Grade 1
Toxicities due to prior radiotherapy that have not resolved to Grade ≤ 1 CTCAE v5.0 at least 21 days prior to the first treatment
Untreated, unstable or uncontrolled central nervous system (CNS) metastases
Any other type of anti-cancer therapy within 21 days of the first dose of study treatment. Use of any other type of anti-cancer treatment is prohibited throughout the study
Patients with increased bleeding risk
Presence of severe cardiac dysfunction
Pulmonary embolism or deep vein thrombosis within 3 months prior to the first dose of study drug
Concurrent malignancy within 5 years prior to entry
Uncontrolled or poorly controlled hypertension
History of ventricular tachycardia, or torsade des pointes
History of moderate to severe dyspnea at rest
Major surgery within 4 weeks of the first dose of study treatment and not fully recovered. Minor surgery within 2 weeks prior to study treatment
Known allergic reactions to any component or excipient of MRG004A or known allergic reactions to other prior anti-TF (including investigational) or other monoclonal antibody ≥ Grade 3
Patients who have any known liver disease, including chronic hepatitis B, hepatitis C, autoimmune hepatic disorders, primary biliary cirrhosis or sclerosing cholangitis; Patients who have concurrent, serious, uncontrolled infections or known infection with HIV, or have a diagnosed acquired immunodeficiency syndrome (AIDS); or an uncontrolled autoimmune disease, or have undergone organ transplant
Active uncontrolled bacterial, viral, fungal, rickettsial, or parasitic infection
Use of systemic corticosteroids within 4 weeks prior to the first dose of treatment
Use of strong CYP3A4 inhibitors or inducers with MRG004A
Other excluded medications or treatment: therapeutic anti-coagulative, or long-term anti-platelet treatment; multivitamins, calcium, vitamin D, and prophylactic anti-RANKL (denosumab) and zoledronic acid therapies for bone metastases are allowed
Any patient with a positive pregnancy or is breast-feeding
Any severe and/or uncontrolled systemic disease that at the discretion of investigator and sponsor makes it undesirable for the patient to participate in this study
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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