68Ga-NOTA-RM26 PET/CT for the Detection of Gastrointestinal Stromal Tumor
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- STATUS
- Recruiting
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- End date
- Aug 31, 2022
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- participants needed
- 30
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- sponsor
- Peking Union Medical College Hospital
Summary
This is an open-label positron emission tomography/computed tomography (PET/CT) study to investigate the diagnostic performance and evaluation efficacy of 68Ga-NOTA-RM26 in Gastrointestinal stromal tumorGISTpatients. A single dose of 55.5 to 148 MBq(1.5-4 mCi) of 68Ga-NOTA-RM26 will be injected intravenously. Patients underwent whole-body PET/CT scans at 30-90 minutes after intravenous injection.
Description
Rm26 is a bioactive polypeptide containing 9 amino acid residues, which can specifically bind to gastrin releasing peptide receptor (GRPR, BB2 receptor). Previous studies have confirmed that there are a large number of GRPR receptors in human common types of tumors, such as lung cancer, breast cancer, prostate cancer, head and neck squamous cell carcinoma, glioma and gastrointestinal tumors. Therefore, the use of various radionuclide labeled gastrin releasing peptide receptor analogues RM26 for tumor targeted imaging and treatment greatly improves the early detection rate of tumor, and has important clinical significance and value in tumor staging, prognosis evaluation and curative effect evaluation.This prospective pilot study investigated the use of 68Ga-NOTA-RM26, an antagonist targeting gastrin-releasing peptide receptor (GRPR), for evaluating breast cancer using positron-emission tomography/computed tomography (PET/CT).
Details
| Condition | gastrointestinal stromal tumor, gastrointestinal stromal tumors, gist |
|---|---|
| Treatment | 68Ga-NOTA-RM26 |
| Clinical Study Identifier | NCT05001204 |
| Sponsor | Peking Union Medical College Hospital |
| Last Modified on | 18 August 2021 |
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