Multi-omics Research of Idopathic Normal Pressure Hydrocephalus (iNPH)

  • End date
    Dec 30, 2022
  • participants needed
  • sponsor
    Second Affiliated Hospital, School of Medicine, Zhejiang University
Updated on 18 August 2021


The research is designed to study the prognostic factors of ventriculoperitoneal (VP) shunt for iNPH by multi-omics research


Preoperative T1-MRI, functional MRI and diffusion MRI imaging data of iNPH patients were collected. The clinical assessment was performed before/after the lumbar puncture test and 6 months after VP shunt. Clinical assessment included Mini-mental State Examination (MMSE), gait scores, Kiefer score, and Modified Rankin Scale (mRS). The cerebrospinal fluid was collected by tap-test, and 6 months after surgery by puncturing in the VP device pump.

Methods- The primary methods used are:

  1. The cerebrospinal fluid proteomic analysis of iNPH patients before and after VP shunt surgery.
  2. The structral and functional MRI analysis of iNPH patients
  3. The clinical assessment of MMSE, gait scores, Kiefer score, and mRS. Objective- To study the prognostic factors of VP shunt for iNPH.

Condition Idiopathic Normal Pressure Hydrocephalus
Treatment ventriculo-peritoneal shunt, ventriculo-peritoneal shunt
Clinical Study IdentifierNCT04998175
SponsorSecond Affiliated Hospital, School of Medicine, Zhejiang University
Last Modified on18 August 2021


Yes No Not Sure

Inclusion Criteria

Age 60 years
Diagnosis of iNPH based on clinical assessment
Participant is able to give written informed consent

Exclusion Criteria

Combining AD and Parkinson's disease and other nervous system diseases
Participant is not medically available for shunt surgery
Secondary NPH
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