Multi-omics Research of Idopathic Normal Pressure Hydrocephalus (iNPH)
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- STATUS
- Recruiting
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- End date
- Dec 30, 2022
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- participants needed
- 40
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- sponsor
- Second Affiliated Hospital, School of Medicine, Zhejiang University
Summary
The research is designed to study the prognostic factors of ventriculoperitoneal (VP) shunt for iNPH by multi-omics research
Description
Preoperative T1-MRI, functional MRI and diffusion MRI imaging data of iNPH patients were collected. The clinical assessment was performed before/after the lumbar puncture test and 6 months after VP shunt. Clinical assessment included Mini-mental State Examination (MMSE), gait scores, Kiefer score, and Modified Rankin Scale (mRS). The cerebrospinal fluid was collected by tap-test, and 6 months after surgery by puncturing in the VP device pump.
Methods- The primary methods used are:
- The cerebrospinal fluid proteomic analysis of iNPH patients before and after VP shunt surgery.
- The structral and functional MRI analysis of iNPH patients
- The clinical assessment of MMSE, gait scores, Kiefer score, and mRS. Objective- To study the prognostic factors of VP shunt for iNPH.
Details
| Condition | Idiopathic Normal Pressure Hydrocephalus |
|---|---|
| Treatment | ventriculo-peritoneal shunt, ventriculo-peritoneal shunt |
| Clinical Study Identifier | NCT04998175 |
| Sponsor | Second Affiliated Hospital, School of Medicine, Zhejiang University |
| Last Modified on | 18 August 2021 |
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