Effect of Acupuncture on the Clinical Outcome of IVF-ET in Patients With Recurrent Implantation Failure

  • STATUS
    Recruiting
  • End date
    Dec 31, 2023
  • participants needed
    310
  • sponsor
    ShangHai Ji Ai Genetics & IVF Institute
Updated on 18 August 2021

Summary

In order to explore the effect of acupuncture on the clinical outcome of IVF-ET in patients with recurrent implantation failure, the patients divide into the experimental group or the control group. In the experimental group, those patients undergo acupuncture at the beginning of embryo transfer cycle three times a week until 14 days after embryo transfer. In the control group, those patients do not receive any treatments during embryo transfer cycle. Statistical analysis of the two groups of primary endpoint and secondary endpoint are done.

Description

In the field of assisted reproduction techonology, there are still 10% of patients with recurrent implantation failure. In order to explore the effect of acupuncture on the clinical outcome of IVF-ET in patients with recurrent implantation failure, the patients divide into the experimental group or the control group. In the experimental group, those patients undergo acupuncture at the beginning of embryo transfer cycle three times a week until 14 days after embryo transfer. In the control group, those patients do not receive any treatments during embryo transfer cycle. Both of two group patients are checked including endometrial receptivity index and fill in SAS anxiety scale form. Statistical analysis of the two groups of primary endpoint (clinical pregnancy rate) and secondary endpoint (embryo implantation rate, biochemical pregnancy rate, early pregnancy loss rate, ongoing pregnancy rate, live birth rate)are done.

Details
Condition Acupuncture therapy discipline, Recurrent Implantation Failure, acupuncture treatment, Acupuncture
Treatment Acupuncture
Clinical Study IdentifierNCT04822207
SponsorShangHai Ji Ai Genetics & IVF Institute
Last Modified on18 August 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

A: 3 times embryo transfer failuresand at least accumulated 4 high-quality embryos were transferred
Two times consecutive embryo transfers failures, at least accumulated 4 high-quality embryos were transferred
Undergo IVF / ICSI / PGT
Transfer 1-2 D3 cleavage embryos or blastocysts in IVF / ICSI and transfer 1 blastocyst in PGT
20-38 years old female
Sign the informed consent voluntarily

Exclusion Criteria

Contraindications for pregnancy or assisted reproductive technology
Chromosome abnormality of husband or wife (except polymorphism)
Abnormal gene diseases
Untreated of uterine diseases that affect the uterine cavity morphology (uterine malformation, submucous myoma, adenomyosis, endometriosis and endometriosis etc.)
AMH < 1.1ng/ml or AFC < 7
The most thickness of endometrium is less than 7 millimeter
Those who have more than 2 times clinical pregnancy abortion
Patients with serious primary diseases including cardiovascular, cerebrovascular, liver, kidney and hematopoietic system and mental diseases
The treatment (such as acupuncture and traditional Chinese Medicine) related to help pregnancy had been carried out in the last 3 months
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