18F-FDG PET/CT to Evaluate pD-1 Monoclonal Antibody Combined With First-line Chemotherapy in Advanced Non-small Cell Lung Cancer

  • STATUS
    Recruiting
  • End date
    Jun 1, 2023
  • participants needed
    50
  • sponsor
    Wuhan Union Hospital, China
Updated on 20 August 2021
cancer chemotherapy
lung carcinoma

Summary

This study is a diagnostic study. Subjects were enrolled from clinical stage IIIB or IV NSCLC patients who received standard first-line chemotherapy combined with PD-1 monoclonal antibody immunotherapy and received 18F-FDG PET/CT imaging before treatment, after 2 courses of treatment, and at the time of disease progression.At the same time, the blood routine, liver and kidney function, inflammatory indexes and other laboratory data of the subjects participating in the study were collected. Based on 18F-FDG PET Ipercist standard and comprehensive laboratory indicators, the subjects were evaluated for tumor biological characteristics prediction and clinical staging, PD-1 immune efficacy monitoring and evaluation, tumor recurrence monitoring and re-staging. At the same time, the systemic immune response and immune-related adverse events during the treatment process were evaluated in order to establish a better evaluation standard and system for the comprehensive evaluation of PD-1 immunotherapy.This study plans to set the sample size as 50 cases.

Details
Condition Non-Small Cell Lung Cancer, nsclc
Clinical Study IdentifierNCT04996927
SponsorWuhan Union Hospital, China
Last Modified on20 August 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Adult patients (age 18 or above), gender unlimited
Pathological diagnosis of non-small cell lung cancer stage IIIB or above
Agree to carry out the standard first-line chemotherapy combined with immunosuppression established in this study
Consent to 18F-FDG PET/CT imaging and related laboratory examination before and during treatment
The patients themselves or their legal representatives are aware of this study and can sign the informed consent

Exclusion Criteria

Acute systemic diseases and electrolyte disturbances
Pregnant or lactating women
The patient or his legal representative is unable or unwilling to sign the informed consent
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