Risk-guided Disease Management Plan to Prevent Heart Failure in Patients Treated With Previous Chemotherapy (REDEEM)

  • End date
    Dec 31, 2023
  • participants needed
  • sponsor
    Baker Heart and Diabetes Institute
Updated on 13 July 2022
heart failure
rehabilitation program
Accepts healthy volunteers


This is a prospective study in which a process of identifying and reducing heart failure (HF) risk will be applied to cancer survivors >65 years old with chemotherapy >10 years ago.

The overall goal of this study to identify the feasibility and value of risk-guided cardiac rehabilitation (exercise, risk factor modification, and behavioural support) as a component of survivorship care.


Participants enrolled in this study will be randomized to cardio-oncology disease management plan ( CO-DMP) that involves the use of surveillance imaging to detect subclinical left ventricular dysfunction (LVD), clinical review to ensure optimal risk factor control and cardio-protection and exercise/sedentariness intervention. The intervention will be delivered over a period of 12 months. The outcome from this study will show that subclinical LVD is more common among long term cancer survivors, and a CO-DMP is feasible in reducing HF risk factors in this sub group of survivors.

Condition Heart Failure
Treatment Usual Care, Heart Failure intervention (Cardio-Oncology Disease Management Plan (CO-DMP)
Clinical Study IdentifierNCT04962711
SponsorBaker Heart and Diabetes Institute
Last Modified on13 July 2022


Yes No Not Sure

Inclusion Criteria

History of cancer > 10 years ago
Have received potentially toxic chemotherapy Anthracycline (any dose) Trastuzumab (Herceptin) in breast-cancer with the HER2 mutation OR Tyrosine kinase inhibitors (e.g. sunitinib) OR Left chest radiotherapy

Exclusion Criteria

Ejection fraction at baseline echo <50%
Valvular stenosis or regurgitation of >moderate severity
History of previous heart failure (baseline New York Heart Association (NYHA) classification >2)
Systolic BP <110 mmHg
Pulse <60/minute if not on beta blocker
Inability to acquire interpretable images (identified from baseline echo)
Contraindications to beta blockers or angiotensin-converting enzyme inhibitors
Oncologic (or other) life expectancy <12 months or any other medical condition (including pregnancy) that results in the belief (deemed by the Chief Investigators) that it is not appropriate for the patient to participate in this trial
Already taking both angiotensin converting enzyme inhibitors/angiotensin receptor blockers and beta blockers, or intolerance (or allergy) to both
Unable to provide written informed consent to participate in this study
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