Endoscopic Ultrasound PANcreatic CAncer RaDIofrequeNcy AbLation

  • End date
    Jan 30, 2028
  • participants needed
  • sponsor
    The University of Texas Health Science Center, Houston
Updated on 4 October 2021


The objectives of this study are to determine the feasibility, tolerability, and treatment effect of Endoscopic Ultrasound (EUS) Radiofrequency ablation (RFA) plus standard-of-care Neoadjuvant chemotherapy (NAC) in the treatment of Pancreatic Ductal Adenocarcinoma (PDAC).

Endoscopic Ultrasound (EUS) Radiofrequency ablation (RFA) and Neoadjuvant chemotherapy (NAC) will be performed before tumor resection surgery, with the goal of shrinking a tumor or stopping the spread of cancer so that surgery might be less invasive and more effective.

Condition Pancreatic Ductal Adenocarcinoma
Treatment Endoscopic Ultrasound (EUS) Radiofrequency Ablation (RFA), Endoscopic Ultrasound (EUS)-Guided Radiofrequency Ablation (RFA), Neoadjuvant chemotherapy (NAC)
Clinical Study IdentifierNCT04990609
SponsorThe University of Texas Health Science Center, Houston
Last Modified on4 October 2021


Yes No Not Sure

Inclusion Criteria

Diagnosed and histologically confirmed PDAC by biopsy
Permanent street address and consent to study participation
Axial CT scan consistent with PDAC
No prior chemotherapy or less than 2 months of pre-operative chemotherapy for PDAC
Eastern Cooperative Oncology Group (ECOG) performance status 0-2

Exclusion Criteria

No phone number of Male or Female patients > 18 years of age
Diagnosed and histologically confirmed PDAC by biopsy
No permanent street address or telephone number
Pregnant patients
Inmates or prisoners
Unable to provide informed consent
Clear my responses

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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