Evaluation of the Effect of Laser Acupuncture on Taxane Acute Pain Syndrome Patients

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    Chang Gung Memorial Hospital
Updated on 13 August 2021
pain reliever
acute pain


This is a prospectively randomized and double-blinded clinical study. Cancer patients were suffered from the taxanes-induced joint pain, and would be advised to receive laser acupuncture in specific points to relieve pain. Clinical effects of analgesic changes would be evaluated before and after the intervention. The inflammation associated indices would be further analyzed to reveal the therapeutic mechanism of laser acupuncture. The laser acupuncture was expected to relief taxanes-induced adverse effects in patients and also can improve patients' life quality.


The current clinical study is prospectively randomized and double-blinded, and practice in Chang Gung Memorial Hospital in Linkou, TaoYuan and Taipei branches. All 90 participants suffered from taxanes-induced myalgia and Arthralgia, and will be randomly assigned into the experimental groups (45 participants) and the control group (45 participants). The experiment group would arrange laser acupuncture on day1 and day3 after Taxanes treatment, besides the control group arrange pseudo-laser acupuncture. In the mean while, blood tests were performed with the C-Reactive protein, erythrocyte sedimentation rate, Interleukin-6 for each participants. Evaluation would be records on day1, day3, and day 8 after Taxanes treatment.

Condition Pain Cancer, Chronic Leg Pain, Arthralgia, Pain, pain, joint, Post-Surgical Pain, arthralgias, Pain (Pediatric), joint pain
Treatment Laser acupuncture device, Pseudo-laser acupuncture
Clinical Study IdentifierNCT04872556
SponsorChang Gung Memorial Hospital
Last Modified on13 August 2021


Yes No Not Sure

Inclusion Criteria

Cancer patients received taxanes treatment and complained with myalgia and Arthralgia in the first taxanes treatment course
Age between 20-70 years old
The NRS (numerical rating scale) score of pain increased more than 2 after the treatment
Both 1st and 2nd taxanes treatment with the same dose

Exclusion Criteria

Receiving acupuncture or herbal medicine over past three months
Myalgia and arthralgia were not due to taxanes treatment such osteoarthritis or rheumatic arthritis
Wounds or skin infections over laser acupuncture points
Refuse assign information consent or follow study protocol
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