Immunoinflammatory Regulation of Esketamine in Septic Patients

  • End date
    Dec 31, 2022
  • participants needed
  • sponsor
    Wuhan Union Hospital, China
Updated on 12 August 2021
mechanical ventilation
continuous infusion
inflammatory response


Studies have shown that excessive systemic inflammatory response and concomitant immunosuppression are the main cause of early death in patients with sepsis. Therefore, it is very important to reduce excessive inflammation and improve immunosuppression in the acute phase of sepsis. Clinical studies have shown that esketamine combined with propofol for sedation has been proven to be safe and effective for septic patients in the ICU due to its cardiovascular stability. Previous studies have demonstrated that esketamine has anti-inflammatory effects against depression and surgical stress. Our preliminary experimental studies have found that esketamine had strong anti-inflammatory effects in the acute phase of sepsis. However, it is not clear whether esketamine could reduce excessive inflammation and improve immunosuppression in septic patients primarily sedated with a continuous infusion of propofol.

This intervention study is to investigate whether three consecutive days of intravenous esketamine infusions via infusion pump (0.07 mg/kg/h) could reduce excessive inflammation and improve immunosuppression in septic patients requiring mechanical ventilation in the ICU under sedation primarily with propofol.

Condition sepsis syndrome, immune suppression, Sepsis and Septicemia, Inflammatory Response, systemic infections, sepsis, systemic infection, immunosuppressive therapy, Septicemia, s-ketamine, esketamine, Immunosuppression, inflammatory responses
Treatment Esketamine hydrochloride
Clinical Study IdentifierNCT04843982
SponsorWuhan Union Hospital, China
Last Modified on12 August 2021


Yes No Not Sure

Inclusion Criteria

years old age 60 years old
SOFA score 2
Mechanical ventilation should be required for at least 24 hours when included in the study
Informed consent is obtained

Exclusion Criteria

Age < 18 years old or 60 years old
Previous solid organ or bone marrow transplantation
Autoimmune diseases (rheumatoid arthritis, systemic lupus erythematosus, etc.), or hematologic malignancies (leukemia and lymphoma, etc.)
Received radiotherapy or chemotherapy within the past 30 days, or received immunosuppressant drugs (tripterygium wilfordii, mycophenolate mofetil, cyclophosphamide, FK506, etc.), or continuous treatment with prednisolone more than 10 mg/day (or equivalent doses of the other hormones)
Unstable angina pectoris or myocardial infarction in the past six months
Acute brain injury (traumatic brain injury, subarachnoid hemorrhage, acute ischemic stroke, acute intracranial hemorrhage, acute intracranial infection, etc.)
Poorly controlled hypertension and congestive heart failure
Increased intraocular or intracranial pressure
Chronic kidney disease, received continuous renal replacement therapy in the past 30 days, or acute renal failure requiring CRRT
Severe chronic liver disease (Child-Pugh class B or C)
Alcohol dependence, mental illness or severe cognitive impairment
Pregnancy or lactation
Informed consent is not obtained
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact



Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note