Effect of Anti-hypertensive Medications on the Diagnostic Accuracy in Screening for Primary Aldosteronism

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  • sponsor
    Chongqing Medical University
Updated on 25 January 2022
antihypertensive drugs
hypertensive medication


To evaluate the effect of anti-hypertensive medication on efficiency of primary aldosteronism screening test, and to determine the appropriate diagnostic cutoff valuefor Chinese hypertension patients during antihypertensive drugs therapy.


Aldosterone-Renin ratio (ARR)is currently the most reliable means available for screening for primary aldosteronePA. However, some antihypertensive drugs may cause false positives and false negatives on ARR. Thus, America PA guidelines suggest that antihypertensive drugs should be withdraw or change therapy before screening.

But withdraw/changing the therapy before ARR is inconvenient for patients.

we prepare to start a prospective study through recruiting hypertension patients who needs ARR screening test, completing the ARR screening before and after withdraw/change therapy.

Condition Vascular Diseases, Hyperaldosteronism, Elevated Blood Pressure, high blood pressure, conn, Diabetes and Hypertension, High Blood Pressure (Hypertension), primary aldosteronism, Hypertension, arterial hypertension, High Blood Pressure (Hypertension - Pediatric), primary hyperaldosteronism
Treatment withdraw antihypertensive drugs
Clinical Study IdentifierNCT04991961
SponsorChongqing Medical University
Last Modified on25 January 2022

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