Effect of Anti-hypertensive Medications on the Diagnostic Accuracy in Screening for Primary Aldosteronism (HASA)
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- STATUS
- Recruiting
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- End date
- Dec 31, 2023
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- participants needed
- 330
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- sponsor
- Chongqing Medical University
Summary
To evaluate the effect of anti-hypertensive medication on efficiency of primary aldosteronism screening test, and to determine the appropriate diagnostic cutoff value for Chinese hypertension patients during antihypertensive drugs therapy.
Description
Aldosterone-Renin ratio (ARR)is currently the most reliable means available for screening for primary aldosterone（PA）. However, some antihypertensive drugs may cause false positives and false negatives on ARR. Thus, America PA guidelines suggest that antihypertensive drugs should be withdraw or change therapy before screening.
But withdraw/changing the therapy before ARR is inconvenient for patients.
the investigators prepare to start a prospective study through recruiting hypertension patients who needs ARR screening test, completing the ARR screening before and after withdraw/change therapy.
Details
| Condition | Hypertension, Primary Aldosteronism |
|---|---|
| Treatment | withdraw antihypertensive drugs |
| Clinical Study Identifier | NCT04991961 |
| Sponsor | Chongqing Medical University |
| Last Modified on | 8 March 2022 |
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