Effect of Anti-hypertensive Medications on the Diagnostic Accuracy in Screening for Primary Aldosteronism (HASA)

  • End date
    Dec 31, 2023
  • participants needed
  • sponsor
    Chongqing Medical University
Updated on 8 March 2022
antihypertensive drugs
hypertensive medication
resistant hypertension


To evaluate the effect of anti-hypertensive medication on efficiency of primary aldosteronism screening test, and to determine the appropriate diagnostic cutoff value for Chinese hypertension patients during antihypertensive drugs therapy.


Aldosterone-Renin ratio (ARR)is currently the most reliable means available for screening for primary aldosterone(PA). However, some antihypertensive drugs may cause false positives and false negatives on ARR. Thus, America PA guidelines suggest that antihypertensive drugs should be withdraw or change therapy before screening.

But withdraw/changing the therapy before ARR is inconvenient for patients.

the investigators prepare to start a prospective study through recruiting hypertension patients who needs ARR screening test, completing the ARR screening before and after withdraw/change therapy.

Condition Hypertension, Primary Aldosteronism
Treatment withdraw antihypertensive drugs
Clinical Study IdentifierNCT04991961
SponsorChongqing Medical University
Last Modified on8 March 2022


Yes No Not Sure

Inclusion Criteria

Persistent hypertension >150/100mmHg, including previously diagnosed grade 2 hypertension but well controlled by 1-2 drugs; newly diagnosed hypertension with 3 days blood pressure > 150 / 100mmHg
Resistant hypertension(combined with three antihypertensive drugs and one of them is diuretic but blood pressure is still greater than 140 / 90 mmHg ; or need to combined four anti-hypertensive drugs to control the blood pressure under 140 / 90 mmHg)
Family history of hypertension with early onset (< 40 years old)
Family history of hypertension with early onset (<40 years old) and cerebrovascular accident
Hypertension with spontaneous or diuretic hypokalemia
Hypertensive with adrenal incidentaloma
Hypertensive with OSAS
First-degree relatives of PA patients and with hypertension Stable antihypertensive medication therapy for more than 2 weeks, medication including:β-blockers, CCB, ACEi, ARB, MRA, and other diuretics

Exclusion Criteria

Patients hard to change or stop the medication for accomplish the screening test or diagnosis Unwilling to participate the study and refuse to sign on informed consent Patients who was diagnosed with other secondary hypertension Suspected with PA(rein concretion beyond the limit of normal reference range after stoping or changing the medication) Severe renal insufficiency (eGFR<30 ml/min/1.73m2); pregnancy
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