Brain-based Understanding of Individual Language Differences After Stroke

  • STATUS
    Recruiting
  • End date
    Aug 30, 2028
  • participants needed
    400
  • sponsor
    Georgetown University
Updated on 11 August 2021

Summary

Strokes often cause a loss of communication ability, referred to as aphasia, as well as cognitive difficulties. Each stroke survivor has a unique pattern of strengths and weaknesses in communication and cognition, and a unique course of recovery. The BUILD study aims to understand the brain basis of these individual differences in stroke outcome. Participants with stroke as well as controls matched in age, educational background, race, and sex are examined using a combination of standardized and in-house tests of language and cognition to provide a detailed profile of strengths and weaknesses. Each participant will have between three and six sessions, including an MRI to measure details of the structure, function, and connections in the brain. The data are analyzed to test how patterns in the stroke lesion explain the patterns of communication and cognitive difficulties, and how patterns in the uninjured parts of the brain explain resilience and recovery from the stroke. Ultimately, we hope that BUILD will guide us toward new targets for brain stimulation treatments or other biologically based treatments that improve language and cognitive abilities after stroke.

Details
Condition alexia, Stroke, Cerebrovascular accident, cerebrovascular accidents, Aphasia, Dyslexia, strokes, cerebral, Speech Disorders, SPEECH DISORDER, Learning disability, Learning Disorders
Clinical Study IdentifierNCT04991519
SponsorGeorgetown University
Last Modified on11 August 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Stroke Survivors
Age >=18
Stroke in left hemisphere of brain with or without aphasia, or stroke elsewhere causing aphasia
Learned English at 8 years or younger
Controls
Age >=18
No history of brain injury resulting from stroke, trauma, infection (i.e. encephalitis), or tumor
Learned English at 8 years or younger

Exclusion Criteria

History of other brain conditions that could impact interpretation of results (such as multiple sclerosis, premorbid dementia)
Severe psychiatric condition that would interfere with participation in the study
History of a learning disability that could impact interpretation of results
Additional Exclusion Criteria for MRIs
Pacemaker or magnetic metal in the body that is not MRI compatible
Pregnancy
Claustrophobia
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact

site

0/250

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider

Loading...

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 

 • 

Private

Reply by • Private
Loading...

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.
Loading...

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note