Brain-based Understanding of Individual Language Differences After Stroke

  • End date
    Aug 30, 2028
  • participants needed
  • sponsor
    Georgetown University
Updated on 11 August 2021


Strokes often cause a loss of communication ability, referred to as aphasia, as well as cognitive difficulties. Each stroke survivor has a unique pattern of strengths and weaknesses in communication and cognition, and a unique course of recovery. The BUILD study aims to understand the brain basis of these individual differences in stroke outcome. Participants with stroke as well as controls matched in age, educational background, race, and sex are examined using a combination of standardized and in-house tests of language and cognition to provide a detailed profile of strengths and weaknesses. Each participant will have between three and six sessions, including an MRI to measure details of the structure, function, and connections in the brain. The data are analyzed to test how patterns in the stroke lesion explain the patterns of communication and cognitive difficulties, and how patterns in the uninjured parts of the brain explain resilience and recovery from the stroke. Ultimately, we hope that BUILD will guide us toward new targets for brain stimulation treatments or other biologically based treatments that improve language and cognitive abilities after stroke.

Condition alexia, Stroke, Cerebrovascular accident, cerebrovascular accidents, Aphasia, Dyslexia, strokes, cerebral, Speech Disorders, SPEECH DISORDER, Learning disability, Learning Disorders
Clinical Study IdentifierNCT04991519
SponsorGeorgetown University
Last Modified on11 August 2021


Yes No Not Sure

Inclusion Criteria

Stroke Survivors
Age >=18
Stroke in left hemisphere of brain with or without aphasia, or stroke elsewhere causing aphasia
Learned English at 8 years or younger
Age >=18
No history of brain injury resulting from stroke, trauma, infection (i.e. encephalitis), or tumor
Learned English at 8 years or younger

Exclusion Criteria

History of other brain conditions that could impact interpretation of results (such as multiple sclerosis, premorbid dementia)
Severe psychiatric condition that would interfere with participation in the study
History of a learning disability that could impact interpretation of results
Additional Exclusion Criteria for MRIs
Pacemaker or magnetic metal in the body that is not MRI compatible
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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