A Trial of the Safety, Tolerability, and Pharmacodynamics of CVL-871 in Subjects With Dementia-Related Apathy

  • End date
    Jun 30, 2023
  • participants needed
  • sponsor
    Cerevel Therapeutics, LLC
Updated on 7 October 2022
Abby Li
Primary Contact
Toronto, Ontario (7.2 mi away) Contact
+21 other location


The purpose of this study is to determine whether CVL-871 is safe and tolerable in patients with Dementia-Related Apathy and if CVL-871 shows changes in clinical measurements of apathy.

Condition Apathy in Dementia
Treatment Placebo, CVL-871 1.0 mg, CVL-871 3.0 mg
Clinical Study IdentifierNCT04958031
SponsorCerevel Therapeutics, LLC
Last Modified on7 October 2022


Yes No Not Sure

Inclusion Criteria

Meets diagnostic criteria for apathy in neurocognitive disorders
Mild to Moderate Dementia (AD, FTD, VAD, or DLB)
Clinically significant apathy

Exclusion Criteria

Other significant psychiatric disorder(s)
Other neurological disorders (other than AD, FTD, VAD, or DLB)
Clear my responses

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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