Molecular Characteristics of Brodalumab in Hidradenitis Suppurativa

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  • sponsor
    Rockefeller University
Updated on 2 July 2022


Hidradenitis suppurativa is a disease involving skin folds, causing swelling of the skin and surrounding tissues, pain, and foul-smelling discharges. Effective treatment options are lacking. Recently, clinical trials conducted in our lab found Brodalumab was an effective drug for this disease. Weekly dosing achieved superior therapeutic outcomes compared to a dosing given once in every other week. Brodalumab was safe in both regimens, but blood and tissue studies to better understand this response are still needed. By performing this small pilot study and collecting blood and tissue samples from participants treated with Brodalumab once weekly we would like to better characterize the molecular response to this treatment, identify blood and tissue markers reflecting disease severity, and better understand disease mechanisms.

Condition Hidradenitis Suppurativa, Acne Inversa
Treatment Brodalumab
Clinical Study IdentifierNCT04979520
SponsorRockefeller University
Last Modified on2 July 2022

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