Assessment of the Quality of Life of Patients With Lymphomas Treated With Oral Therapy (EVEREST)

  • End date
    Jan 1, 2025
  • participants needed
  • sponsor
    University Hospital, Toulouse
Updated on 11 May 2022


The emergence of new anti-cancer drugs orally administered has revolutionized the prognosis and modalities of management of several lymphomas over the past decade. Today, half of patients receive oral therapy at home. Ibrutinib, acalabrutinib, idelalisib, venetoclax and lenalidomide are oral therapies used in the treatment of Chronic Lymphoid Leukemia, Follicular Lymphoma, Waldenström's disease and mantle cell lymphoma, in relapsing but soon to be 1st line.

Nevertheless, clinical trials leading to marketing authorizations for these drugs were performed in a small number of patients and very little data is available on their use in real life conditions. Their impact on the quality of life of patients also remains to be assessed.

The aim of this clinical research is to evaluate quality of life of patients at the initiation of the first oral therapy and every year for 5 years. This study will also identify factors (biological and non-biological: quality of life, shared decision-making ...) associated with a good response of patients and follow-up for the occurrence of long-term adverse reactions (5 years).


Prospective longitudinal cohort. This observational study is monocentric. For each patient, data will be collected during 5 years.

Condition Quality of Life
Treatment Questionnaire
Clinical Study IdentifierNCT04985214
SponsorUniversity Hospital, Toulouse
Last Modified on11 May 2022


Yes No Not Sure

Inclusion Criteria

Patients included in the PK-E3i clinical study OR
Over the age of 18
Patients with hemopathies and starting treatment with oral therapy (idelalisib, ibrutinib, venetoclax, lenalidomide, acalabrutinib…)
Be able to understand the objective and the constraints related to research
Patient having read the information notice and the non-objection form
Social Security affiliation

Exclusion Criteria

Pregnant women
Persons under legal protection of adults
Patients under judicial protection
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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