Nitroglycerine Versus Dexmedetomidine Infusion in Intraoperative Management of Uncontrolled Hypertension

  • STATUS
    Recruiting
  • End date
    Mar 7, 2022
  • participants needed
    60
  • sponsor
    National Cancer Institute, Egypt
Updated on 7 August 2021
anesthesia
cancer
hypertension
uncontrolled hypertension

Summary

This study aim to compare the efficacy of intraoperative dexmedetomidine infusion versus Nitroglycerin infusion in cancer patients with accidental uncontrolled intraoperative elevation of blood pressure.

Description

Nitroglycerine is a direct vessel wall vasodilator with more venodilator effect than arterial dilator effect. It is used as an anti-anginal and antihypertensive drug. On the other hand, dexmedetomidine is a highly selective alpha 2 adrenergic agonist with sympatholytic effect. This study aim to compare the efficacy of intraoperative dexmedetomidine infusion versus Nitroglycerin infusion in cancer patients with accidental uncontrolled intraoperative elevation of blood pressure.

Details
Condition Vascular Diseases, Hypertension, Elevated Blood Pressure, high blood pressure, arterial hypertension
Treatment Dexmedetomidine, nitroglycerin
Clinical Study IdentifierNCT04953156
SponsorNational Cancer Institute, Egypt
Last Modified on7 August 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Cancer patients with controlled hypertension and undergoing surgical procedures under general anesthesia
Age 18 years

Exclusion Criteria

patient refusal
patients on Beta blockers
kidney or liver function impairment
bradycardia, any degree of heart block and severe cardiorespiratory disease
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