Clinical Efficacy and sAfety of Intravenous Infusion of Nicorandil During Primary Percutaneous Coronary Intervention (CLEAN)

  • End date
    Dec 31, 2023
  • participants needed
  • sponsor
    Fudan University
Updated on 9 August 2022
percutaneous coronary intervention
reperfusion therapy


The investigators evaluate the efficacy and safety of intravenous administration of nicorandil as adjuncts to reperfusion treatment in acute ST-segment elevation acute myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI).

Condition ST Elevation Myocardial Infarction, Percutaneous Coronary Intervention
Treatment Placebo, Nicorandil
Clinical Study IdentifierNCT04665648
SponsorFudan University
Last Modified on9 August 2022


Yes No Not Sure

Inclusion Criteria

-80 years
acute ST-segment elevation myocardial infarction within 12 hours of symptom onset

Exclusion Criteria

systolic blood pressure<100mmHg
cardiac shock
aortic dissection
history of myocardial infarction or percutaneous coronary intervention or coronary artery bypass grafting (<6 month)
history of the treatment of nicorandil (<6 month)
history of intravenous nitrates before percutaneous coronary intervention
contraindicated or intolerable to nicorandil
pregnant or lactation period
patients with an estimated survival time of less than 1 year
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