Bio-Banking of Specimens for Advanced Lung Disease and Lung Transplant Research

  • STATUS
    Recruiting
  • End date
    Dec 1, 2026
  • participants needed
    100
  • sponsor
    Baylor Research Institute
Updated on 3 August 2021
lung transplant

Summary

A major goal of this protocol is to support biomarker studies in advanced lung diseases, lung transplantation care, and to improve our understanding of the effects of viral and other infectious exposures to outcomes in our lung transplant and ALD patient populations.

Description

The identification of biomarkers in a patient's blood or tissue that are specific for particular medical conditions (such as interstitial lung disease, chronic obstructive lung disease (COPD), and post-lung transplant rejection) is important for the prevention and early detection of the disease, as well as to advance our understanding of targeted therapies. Availability of biomarkers for diagnosis and for the prediction of patient prognosis and therapy promises personalized medicine. Patients may be selected based on the presence of particular gene mutations or circulating protein levels to receive personalized treatment. Furthermore, knowledge regarding genetic risk and susceptibility to infectious diseases as well as structural lung disease is rapidly growing-as whole genome sequencing and genome-wide association studies have become easier to do, genetic risk has emerged as increasingly important in understanding why and how some patients develop chronic lung disease. This is true for the spectrum of lung diseases treated in the ALD program, from those with airways diseases such as COPD to diffuse parenchymal lung diseases such as idiopathic pulmonary fibrosis (IPF). The availability of human biological specimens for research purposes is crucial for the advancement of medical knowledge of understanding, diagnosing, and treating chronic lung diseases and optimizing post-lung transplant care.

Details
Condition pulmonary diseases, Lung Disease, interstitial lung diseases, Pulmonary Fibrosis, lung diseases, Respiratory Failure, pulmonary disorders, Pulmonary Disease, Interstitial lung disease
Treatment Patient Biospecimen Registry (observational and blood sampling)
Clinical Study IdentifierNCT04664192
SponsorBaylor Research Institute
Last Modified on3 August 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

All individuals aged 18 years and older
Persons who have undergone lung transplantation at Baylor University Medical Center in the previous 10 years
Individual is able to understand and sign the informed consent form

Exclusion Criteria

Significant documented anemia (hemoglobin <8 g/dL)
Blood transfusions within past 3 weeks
Active cancer (non-skin cancers)
Enrollment against doctor recommendation
Patient not able to provide informed consent
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  • You can expect the study team to contact you via email or phone in the next few days.
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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