Lysophosphatidic Acid / Autotaxin Axis in Rheumatoid Lung Disease
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- STATUS
- Recruiting
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- End date
- Sep 5, 2023
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- participants needed
- 40
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- sponsor
- Hospices Civils de Lyon
Summary
Rheumatoid arthritis (RA) is a common chronic systemic autoimmune relapsing disease characterized by joint inflammation. Beside arthritis leading to progressive joint damage and loss of function, RA is also associated to extraarticular inflammatory conditions such as interstitial lung disease (ILD). This one develops in 30% of all RA patients with a median survival expectancy of 3 to 10 years once symptomatic. Unfortunately, there is no medical care recommendation so far as the pathophysiology is unknown. However, ILD share many similarities with idiopathic pulmonary fibrosis (IPF).
Autotaxin (ATX), due to its lysophospholipase activity, produces a bioactive lipid, lysophosphatidic acid (LPA) under inflammation. LPA has pleiotropic actions inducing cell proliferation, survival, motility and differentiation. Increased ATX and LPA levels have been detected in synovial fluid of RA patients and in IPF patients. ATX is also currently the target for a phase 3 clinical trial in IPF.
Given the previous described role of ATX/LPA axis in arthritis and inflammation-induced bone loss in RA and the similarities between RA-ILD and IPF, the investigators hypothesized that ATX/LPA axis may be also an attractive drug target for this pulmonary condition in RA and therefore that ATX and LPA may be increased in sputum from RA patients with ILD in comparison with sputum from RA patients without ILD.
Details
| Condition | Rheumatoid Arthritis, Rheumatoid Arthritis (Pediatric) |
|---|---|
| Treatment | Quantitative ATX and LPA determination in plasma and sputum |
| Clinical Study Identifier | NCT04284735 |
| Sponsor | Hospices Civils de Lyon |
| Last Modified on | 5 August 2021 |
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