Lysophosphatidic Acid / Autotaxin Axis in Rheumatoid Lung Disease

  • End date
    Sep 5, 2023
  • participants needed
  • sponsor
    Hospices Civils de Lyon
Updated on 5 August 2021
interstitial lung disease


Rheumatoid arthritis (RA) is a common chronic systemic autoimmune relapsing disease characterized by joint inflammation. Beside arthritis leading to progressive joint damage and loss of function, RA is also associated to extraarticular inflammatory conditions such as interstitial lung disease (ILD). This one develops in 30% of all RA patients with a median survival expectancy of 3 to 10 years once symptomatic. Unfortunately, there is no medical care recommendation so far as the pathophysiology is unknown. However, ILD share many similarities with idiopathic pulmonary fibrosis (IPF).

Autotaxin (ATX), due to its lysophospholipase activity, produces a bioactive lipid, lysophosphatidic acid (LPA) under inflammation. LPA has pleiotropic actions inducing cell proliferation, survival, motility and differentiation. Increased ATX and LPA levels have been detected in synovial fluid of RA patients and in IPF patients. ATX is also currently the target for a phase 3 clinical trial in IPF.

Given the previous described role of ATX/LPA axis in arthritis and inflammation-induced bone loss in RA and the similarities between RA-ILD and IPF, the investigators hypothesized that ATX/LPA axis may be also an attractive drug target for this pulmonary condition in RA and therefore that ATX and LPA may be increased in sputum from RA patients with ILD in comparison with sputum from RA patients without ILD.

Condition Rheumatoid Arthritis, Rheumatoid Arthritis (Pediatric)
Treatment Quantitative ATX and LPA determination in plasma and sputum
Clinical Study IdentifierNCT04284735
SponsorHospices Civils de Lyon
Last Modified on5 August 2021


Yes No Not Sure

Inclusion Criteria

Patient with a history of asthma, COPD or any other pulmonary pathology or pulmonary symptom unrelated to PID
Non-inclusion criteria for control patients (RA patients without PID)
Patient with a history of asthma, COPD, any other pulmonary pathology, any pulmonary symptom or any pulmonary CT abnormality

Exclusion Criteria

General exclusion criteria
Vulnerable patient within the meaning of current French legislation (deprived of liberty by judicial or administrative decision, under guardianship or curatorship or under the protection of justice)
Patient not fluent in French
Woman breastfeeding or planning a pregnancy for the duration of the study
Patient in exclusion period after participating in another clinical trial or in the process of participating in another clinical trial involving an experimental product
Patient with occupational exposure to particles known to be responsible for PID (silica, etc.)
Patient with an autoimmune disease other than RA or an auto-inflammatory disease
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