Detection of Small Fiber Neuropathy Using Skin Properties

  • STATUS
    Recruiting
  • End date
    Feb 1, 2023
  • participants needed
    400
  • sponsor
    Brigham and Women's Hospital
Updated on 6 August 2021
Investigator
Peter Novak, MD
Primary Contact
Brigham and Women's Faulkner Hospital (5.4 mi away) Contact
burning
skin biopsy
nerve damage

Summary

Small fiber neuropathy affects millions of peoples worldwide. The neuropathy is causing disabling burning pain and dysautonomia such as dizziness with standing, brain fog, fatigue, constipation, too much or too little sweating. The detection of nerve damage is complicated and not widely available; it requires either skin biopsy or specialized equipment and training. This project utilizes the mathematical processing of skin pictures for the purpose to extract the statistical features related to loss of small fibers. This approach can improve the availability of diagnosis of small fiber neuropathy.

Description

Small fiber neuropathy, including cardiovascular diabetic neuropathy, affects millions of peoples worldwide. The neuropathy is causing disabling burning pain and dysautonomia such as dizziness with standing, brain fog, fatigue, constipation, urinary problems and cold or hot intolerance. Early and accurate diagnosis of neuropathy is essential for correct treatment. Available diagnostic methods are either invasive such as skin biopsy or available only in few specialized centers. This project addresses the limited availability of small fiber neuropathy detection.

The project utilizes utilize specialized image processing of skin pictures for the purpose to extract the statistical features that are related to loss of small fibers. The accuracy of the diagnosis verified using skin biopsies.

This approach can improve the availability of diagnosis of small fiber neuropathy.

Details
Condition Peripheral Neuropathy, Small Fiber Neuropathy
Treatment Image processing of skin
Clinical Study IdentifierNCT04759443
SponsorBrigham and Women's Hospital
Last Modified on6 August 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients with age 18 year or older
Patients that sign the informed consent form to participate in this study
Patients completed the autonomic testing with skin biopsies

Exclusion Criteria

Patients with significant hairs at the legs that will cover the skin
Any dermatological disorder that can affect the skin composition
The use of skin lotion
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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