Papillomavirus Load in Rheumatic Inflammatory Diseases

  • STATUS
    Recruiting
  • End date
    Jan 9, 2024
  • participants needed
    385
  • sponsor
    Hospices Civils de Lyon
Updated on 1 August 2021

Summary

Rheumatoid arthritis (RA) and spondyloarthritis (SpA) are the two most common chronic inflammatory rheumatism, with a prevalence in the French population of 0.3% and 0.4%, according to the criteria European League Against Rheumatism / American College of Rheumatology (EULAR / ACR) 2010 and Assessemnt of SpondyloArthritis International Society (ASAS) 2009 respectively. In patients whose pathology is resistant to first-line treatment, such as methotrexate for rheumatoid arthritis and peripheral spondyloarthritis, or non-steroidal anti-inflammatory drugs for axial spondyloarthritis, the treatment is based on biotherapies, such as anti-inflammatory drugs. -TNF, to obtain effective control of the disease and prevent joint damage.

Human papillomavirus (HPV) infection, the leading risk factor for cervical carcinoma, is the most common sexually transmitted infection (STI) with a particularly high prevalence among young women.

In addition, anti-TNF, used in the treatment of RA and SpA, and anti-IL6 receptor, used in that of RA, could have opposite effects on HPV-dependent oncogenesis.

Thus, patients with RA or SpA may have a higher risk than the general population of progression to cervical cytological abnormalities. Evaluation of the chronic carriage of HPV would then be a useful tool in the management of these patients.

Details
Condition Spondylarthritis, Spondyloarthropathy, spondyloarthritis, Rhumatoid Arthisis, Rhumatoid Arthisis
Treatment Pregnancy Test, Cervical smear, Cervical smear, Sexual activity questionnary
Clinical Study IdentifierNCT03713736
SponsorHospices Civils de Lyon
Last Modified on1 August 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Woman between 18 and 65 years old
Patient with rheumatoid arthritis as defined in 2010 ACR/EULAR criteria or with spondyloarthritis as defined in 2009 ASAS criteria
Patient able to understand the objectives of the study and give documented informed consent
Patient affiliated to a social security scheme

Exclusion Criteria

Pregnant or breastfeeding patient
Patient with a history of cervical cancer
Patient under juridical protection
Patient unable to provide informed consent due to linguistic or psychic impairment
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