Safety and Efficacy of XmAb18087 ± Pembrolizumab in Advanced Merkel Cell Carcinoma or Extensive-stage Small Cell Lung Cancer

  • End date
    Mar 23, 2024
  • participants needed
  • sponsor
    Xencor, Inc.
Updated on 23 March 2022
lung cancer
bispecific antibody


This is a Phase 1b/2, multiple-dose study designed to describe safety and efficacy, and to assess PK and immunogenicity of XmAb18087 monotherapy and in combination with pembrolizumab in subjects with metastatic Merkel cell (MCC) or locoregional MCC that has recurred after locoregional therapy with surgery and/or radiation therapy, and XmAb18087 monotherapy in subjects with extensive-stage small cell lung cancer (SCLC) that has progressed after standard therapies.

Condition Merkel Cell Carcinoma, Small Cell Lung Cancer
Treatment XmAb18087, XmAb18087 ± Pembrolizumab
Clinical Study IdentifierNCT04590781
SponsorXencor, Inc.
Last Modified on23 March 2022


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