Depression

  • STATUS
    Recruiting
Updated on 30 July 2021
behavior therapy
depressive disorder
depressive symptoms
depressed mood
suicidal
transcranial magnetic stimulation
treatment resistant depression

Summary

Major depressive disorder (MDD), more commonly referred to as depression, is more than just a sad mood or feeling down. The newest research suggests that the symptoms of depression may be due to decreased levels of biomolecules in the brain called 'neurotrophic factors'. These biomolecules support cell growth and survival, and development of new connections between cells.

A deficiency of these biomolecules results in cell loss in important areas of the brain associated with motivation, emotion, perceptions, thinking, learning and memory. Reversing this deficiency with the use of new antidepressant treatments may resolve the symptoms of depression. New antidepressant medications being studied may work much more rapidly and be more effective than currently available treatments.

Depression is challenging. Having MDD can make it much harder for people to complete ordinary day-to-day activities. It may be much more difficult to get out of bed and go to work. Trying to get through the work day may take much greater effort than usual. Even simple day-to-day activities such as bathing, brushing your teeth, doing laundry, and other household chores may seem overwhelming.

If you are symptoms of depression most of the day, nearly every day, you may be experiencing MDD. But you are not alone, it is reported that as many as 7% of the US population meets criteria for major depressive disorder over a 12-month period and women are 1.5-3 times as likely as men to develop MDD.

Some treatments which have been proven to be effective in MDD research studies include antidepressant medications, cognitive behavior therapy, and TMS (transcranial magnetic stimulation). Treatments don't work for all people. Treatments have side effects and some can take 4-6 weeks to become effective. Some individuals experience treatment resistant depression and do not feel adequate results even while taking an antidepressant.

Research is needed to find new, more effective, faster-acting treatment options with fewer side effects. People with MDD experience a depressed mood (persistent feelings of sadness or hopeless) or loss of interest or pleasure most of the day nearly every day.

Other common symptoms of MDD include:
  • Fatigue
  • Low energy
  • Low motivation, needing to push yourself to do day-to-day activities
  • Difficulty getting to sleep or sleeping excessively
  • Loss of appetite or overeating
  • Feeling restless or slowed down
  • Feelings of worthlessness or excessive guilt
  • Trouble concentrating or thinking clearly
  • Indecisiveness
  • Recurrent thoughts of death, and recurrent suicidal thoughts
  • For some, symptoms may persist even when taking an antidepressant

Description

  • Qualified participants receive all study related care, study drug and study related office visits at no cost
  • No insurance is required to participate
  • Compensation may be available
To learn more, please contact the Summit Research Team at 503-228-2273 or visit https://summitresearchnetwork.com/depression/ 
 

Details
Condition Depression, Depression (Major/Severe), Depression (Adult and Geriatric), Depression (Treatment-Resistant)
Clinical Study IdentifierTX278662
Last Modified on30 July 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Be 18 to 65
Clear my responses

How to participate?

Step 1 Connect with a site
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar
Name

Primary Contact

site
Name

0/250
Preferred Language
Other Language
Please verify that you are not a bot.

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider

Loading...

Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 

 • 

Private

Reply by • Private
Loading...

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.
Loading...

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note