GB34 Acupuncture in Acute Cholecystitis

  • STATUS
    Recruiting
  • days left to enroll
    6
  • participants needed
    30
  • sponsor
    Nigde Omer Halisdemir University
Updated on 31 July 2021

Summary

The purpose of this pilot study is to investigate the effects of GB34 acupuncture, performed as adjuvant to standard medical treatment, on clinical response and laboratory parameters of patients with a diagnosis of acute cholecystitis.

Description

Acute cholecystitis is a frequent complication of gallbladder stones. The prevalence of gallbladder stone is 10-15% and in 35% of patients complications and recurrent symptoms develop in their lifetime. Acute cholecystitis is one of the most frequently encountered acute surgical conditions. It is manifested in 3-10% of patients referred to emergency departments with complaints of abdominal pain.

Although the gold standard of therapy is laparoscopic cholecystectomy in symptomatic cholecystitis and related complications, more than 70% of patients respond well to medical treatment at first place. Actually, timing of cholecystectomy was studied extensively, yet is still debatable. Early cholecystectomy is the operation performed within 72 hours of the beginning of the symptoms. Delayed cholecystectomy is the operation performed 6 weeks after the suppression of the inflammation. Investigators perform early cholecystectomy is in cases with perforation and complication like gangrenous or emphysematous acute cholecystitis whereas delayed cholecystectomy is preferred in the remaining patients.

In fact it is known for some time that ear and body acupuncture have modulatory effects on motor functions of gallbladder and even provide some improvement in acute cholecystitis. Previously, studies demonstrating that GB34 has specific effects on the motility of bile ducts were published. More recently, researchers were able to demonstrate that GB34 electro acupuncture have positive effects on gall bladder wall thickness and on WBC levels, by using an experimental rabbit model of acute cholecystitis. Additional functional MR studies were used to distinguish the neural specificity of the acupuncture points. GB34 were found to induce a specific response pattern which is more significant in motor functions in brain. Furthermore it is known for decades that acupuncture other than point specific effects, triggers self-healing mechanisms of the body via endogen pathways.

Details
Condition Acute cholecystitis
Treatment Acupuncture
Clinical Study IdentifierNCT04960189
SponsorNigde Omer Halisdemir University
Last Modified on31 July 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Diagnosed and hospitalised patients with mild acute cholecystitis

Exclusion Criteria

Pregnant women
Immunosuppressive patients
Patients with intermediate and severe acute cholecystitis
Patients with acalculous acute cholecystitis
Patients with uncontrolled diabetes mellitus
Patients with collegen tissue diseases
Patients with malignancies
Patients who are using anti-coagulant or anti-aggregant medications
Patients with blood diseases
Patients with BMI>35
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