New Strategies for Pulmonary Assessment in Spinal and Chest Wall Deformity

  • End date
    Aug 30, 2025
  • participants needed
  • sponsor
    Children's Hospital of Philadelphia
Updated on 22 October 2022


Thoracic insufficiency syndrome (TIS) is a complex condition that involves chest wall deformities that can affect normal breathing and lung growth. In most cases, children with TIS are also born with spine disorders such as scoliosis. The inability of the thorax to support normal respiration or lung growth can cause respiratory distress and even mortality. Investigators aim to validate MRI imaging sequences to use as an assessment tool for pulmonary function.

Condition Thoracic Insufficiency Syndrome
Treatment Xenon-129
Clinical Study IdentifierNCT04977830
SponsorChildren's Hospital of Philadelphia
Last Modified on22 October 2022


Yes No Not Sure

Inclusion Criteria

Males or females 6 to 18 years old diagnosed with thoracic insufficiency syndrome who are undergoing surgery

Exclusion Criteria

patients not diagnosed with thoracic insufficiency syndrome
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