Sentinel Lymph Node Biopsy Predictive Value in Endometrial Cancer of Low and Intermediate Risk

  • End date
    Jul 7, 2023
  • participants needed
  • sponsor
    Moscow City Oncology Hospital No. 62
Updated on 24 October 2021
indocyanine green
adjuvant therapy
endometrial adenocarcinoma


Lymphadenectomy performed for endometrial cancer influences the decision on adjuvant therapy. The aim of this study is to evaluate the rate of change in postoperative treatment based on the result of sentinel lymph node biopsy (SLNB).

Condition Hysterectomy, Endometrial Carcinoma, Uterine Cancer, Sentinel Lymph Node, Endometrial Adenocarcinoma, Sentinel Node, Laparoscopic Hysterectomy, Endometrial Endometrioid Adenocarcinoma, Endometrial Cancer Stage I, Endometrial Cancer Stage II, hysterectomies, stage ii endometrial cancer, endometrioid adenocarcinoma of the endometrium
Treatment Laparoscopic hysterectomy with sentinel lymph node biopsy
Clinical Study IdentifierNCT04972682
SponsorMoscow City Oncology Hospital No. 62
Last Modified on24 October 2021


Yes No Not Sure

Inclusion Criteria

Age 18
Histologically verified low-grade endometrial adenocarcinoma of the endometrium (G1-G2)
Stage IA (FIGO 2009) according to MRI (CT, ultrasound)
Stage IB and II (FIGO 2009) when lymphadenectomy is contraindicated
No contraindications for surgery
Signed informed consent

Exclusion Criteria

Age <18
Signs of tumor spread outside the corpus uteri
No signs of tumor invasion into the myometrium
High-grade tumor (G3)
Bokhman type 2 tumor (serous adenocarcinoma, clear cell adenocarcinoma, carcinosarcoma, endometrial stromal sarcoma, etc.)
Preoperative treatment of endometrial cancer (radiation therapy, chemotherapy or hormone therapy)
Prior pelvic or retroperitoneal lymphadenectomy
Prior surgery on the uterus and uterine appendages (except for cesarean section, tubectomy, ovariectomy, ovarian resection, ovarian biopsy, ovarian cauterization)
Surgical treatment is contraindicated
Allergy to iodine-containing drugs
No signed informed consent
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