Characterization and Pathogenesis of ACLF

  • End date
    Dec 31, 2025
  • participants needed
  • sponsor
    Johann Wolfgang Goethe University Hospital
Updated on 5 August 2021


This single-center prospective observational study aims at characterization of pathogenesis of ACLF. There will be three different cohorts investigated with the main endpoint mortality in these groups.

  1. SAPIENT = Sepsis ACLF patients, to investigate the differences between ACLF and sepsis in cirrhosis
  2. PROACT = Portal mediators as ACLF Targets, to assess portal venous biomarkers in patients receiving TIPS leading to ACLF and identify potential treatment targets
  3. ELITE = prEdictors of beneficial LIver Tx in ACFL patiEnts, to assess in ACLF-patients receiving liver transplantation predictors of survival, which may improve selection of ACLF-patients for liver transplantation Secondary endpoints will be different in the three different cohorts and biological material will be collected for separate ancillary studies.

Condition Acute on Chronic Liver Failure, Liver Disease, Hepatic Fibrosis, LIVER DISEASE, hepatic cirrhosis, Portal hypertension, Liver Disorders, liver cirrhosis, Cirrhosis
Clinical Study IdentifierNCT04975490
SponsorJohann Wolfgang Goethe University Hospital
Last Modified on5 August 2021


Yes No Not Sure

Inclusion Criteria

Liver cirrhosis

Exclusion Criteria

extrahepatic and metastatic malignancy
refusal for participation
decision of attending phycisian
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