Video-oculography and Parkinson's Disease

  • STATUS
    Recruiting
  • End date
    Jan 30, 2029
  • participants needed
    30
  • sponsor
    Association de Recherche Bibliographique pour les Neurosciences
Updated on 25 January 2022
ct scan
datscan
movement disorder
dopa
antiparkinsonian agents

Summary

This study aims to study, in patient with Parkinson's disease, mild to moderate stage (according to Movement Disorder Society Clinical Diagnostic Criteria for Parkinson's Disease, Postuma et al., 2015):

  • the evolution of oculomotricity markers over time.
  • the correlation between neurological evaluations (motor and non-motor scores), neuropsychological evaluations (cognitive disorders) and oculomotricity evaluation, over a follow-up period of 7 years.
  • the impact of antiparkinsonian drugs on the evolution of oculomotricity assessment by video-oculography.
  • the value of oculomotricity assessment by video-oculography as an evolutionary marker of the disease.

Details
Condition Parkinson Disease, Idiopathic
Treatment Video-oculography / Neuropsychological evaluations
Clinical Study IdentifierNCT04731246
SponsorAssociation de Recherche Bibliographique pour les Neurosciences
Last Modified on25 January 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Male or Female
Clinically defined idiopathic Parkinson's Disease (PD)
Brain MRI performed in routine care in the 12 months preceding inclusion
Cerebral DaTSCAN or cerebral PET with F-DOPA, performed as routine care before inclusion (no time limit), confirming presynaptic dopaminergic denervation
Hoehn & Yahr score: 1 to 3
Normal clinical examination of oculomotricity (slight impairment of smooth pursuit accepted)
Neuro-cognitive disorders: absent or minor (according to DSM5)
Sufficient written and oral expression in French
Covered by a health insurance system
Written informed consent signed by the patient
Presence of a caregiver

Exclusion Criteria

Psychiatric comorbidity (except anxiety or mild to moderate depression)
Neurological comorbidity, if significant
Brain MRI showing
significant cerebrovascular pathology (Fazekas I admitted)
another brain disease, including stroke
Major cognitive impairment
Absolute exclusion criteria and "Red flags" of the 2015 criteria orienting towards another degenerative pathology of the extrapyramidal system
Cerebellar syndrome
Vertical oculomotricity disorders on clinical examination
Motor symptoms restricted to the lower limbs
Bilateral and perfectly symmetrical parkinsonism
Early dystonia
Clinical profile suggestive of behavioral variant frontotemporal dementia (bvFTD)
Progressive aphasia or apraxia
Moderate or severe postural instability and / or early falls
Early bulbar dysfunction (dysarthria, swallowing disorders)
Ventilatory dysfunction (inspiration)
Severe dysautonomia
DOPA-resistance
Neuroleptic treatment or related
Normal MIBG myocardial scintigraphy (if performed)
Clear my responses

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