Effect of Electro-acupuncture on Women With Diminished Ovarian Reserve

  • End date
    Dec 29, 2025
  • participants needed
  • sponsor
    Huazhong University of Science and Technology
Updated on 29 July 2021


Diminished ovarian reserve (DOR) is the precursor state of ovarian failure, and can cause the decline of women's reproductive function. Some studies have demonstrated that acupuncture can improve ovarian function. In this trial, we hypothesize that electro-acupuncture is efficient for the ovarian function and the following outcome of IVF-ET in DOR patients.


First, patients will be recruited according to the inclusion criteria and exclusion criteria.

Second, baseline measurements (including ovarian reserve function, blood biochemical index, scores from the self-rating anxiety and depression scale, quality of life) will be taken.

Third, each patient will receive 24 sessions of acupuncture in 2-3 months, twice or three times a week.

Last, the above baseline measurements will be taken again as soon as the treatment is finished and outcome measures will be recorded after the treatment.

Condition Diminished Ovarian Reserve
Treatment Treatment group protocol, Control group protocol
Clinical Study IdentifierNCT04972877
SponsorHuazhong University of Science and Technology
Last Modified on29 July 2021


Yes No Not Sure

Inclusion Criteria

Age < 40, will undergo IVF-ET
Low ovarian reserve: Antral follicle count (AFC)<7, or AMH<1.1ng/ml; or has a history of poor ovarian response: in the last hyper stimulation cycle, the number of retrieved oocytes<3
Spouse' semen examination is normal, or after semen prewash can reach the standard of common IVF or Intracytoplasmic Sperm Injection(ICSI)

Exclusion Criteria

Male with azoospermia
Male/female's chromosome is abnormal
Adenomyosis, uterine fibroids, endometrial polyps, scar uterine, reproductive system tuberculosis, oviduct effusion, pelvic lesions such as ovarian endometriosis cyst or tumor
Female has other endocrine disease: thyroid diseases, hyperprolactinemia, insulin resistance, diabetes, adrenal diseases, etc
Definitively diagnosed autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, antiphospholipid syndrome
Other pathogenesis that leads to recurrent miscarriage or agnogenic recurrent miscarriage
A history of cancer and has received radiotherapy and chemotherapy
Had acupuncture treatment in recent 3 months
Unwilling to sign the informed consent of this study
Clear my responses

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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