Prevalence of Wild-Type Transthyretin Cardiac Amyloidosis Among Patients Undergoing Carpal Tunnel Release Surgery - A Prospective Study

  • STATUS
    Recruiting
  • End date
    Apr 15, 2023
  • participants needed
    25
  • sponsor
    Steen Hvitfeldt Poulsen
Updated on 15 October 2021

Summary

Patients above the age of 60 will be recruited at their carpal tunnel release surgery. Biopsies will be taken from the wrist and examined for the presence of amyloid protein. A amyloid-positive biopsy will refer the patients for cardiac examination.

If the result of the cardiac examination is suspected cardiac amyloidosis, the patient will be referred for a diagnostic TC99-DPD scintigraphy. If the scintigraphy is positive, the patient will be referred for right heart catherization (RHC) and an exercise test.

Myocardial biopsies will be taken at the RHC and examined with electron microscopy and high resolution respirometry.

Details
Condition Wild-Type Transthyretin-Related (ATTR)Amyloidosis, Transthyretin Amyloidosis, Hereditary Transthyretin Amyloidosis, Cardiac Amyloidosis, Transthyretin Cardiac Amyloidosis
Treatment Tenosynovial biopsy
Clinical Study IdentifierNCT04276220
SponsorSteen Hvitfeldt Poulsen
Last Modified on15 October 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Males above 65 years of age, females above 75 years of age
Scheduled idiopathic carpal tunnel release surgery
Informed written consent

Exclusion Criteria

Operation by other indication, e.g
Fracture
Ganglion
Known amyloidosis
Clear my responses

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