Neuroinflammation and Modulating Factors in Depression and HIV

  • End date
    Sep 30, 2022
  • participants needed
  • sponsor
    University of Minnesota
Updated on 31 July 2021
antiretroviral therapy
depressive symptoms
depressed mood
selective serotonin reuptake inhibitors
HIV Vaccine


Determine if depression, which persists after depression treatment at 26 weeks, is associated with increased innate inflammation in a prospective cohort of HIV-infected Ugandans receiving SSRIs in which group psychotherapy is initiated.


Depression in HIV is a complex co-morbidity with both social factors such as stigma as well as biologic components. Disruptions in neurotransmitters such as serotonin and catecholamines are known to cause depression. Inflammation caused by diseases such as stroke, diabetes, and HIV is associated with higher rates of depression. HIV causes inflammation throughout the body, but since the virus can cross the blood-brain-barrier, HIV can replicate in and target the brain causing neuroinflammation which predisposes depression. However the pathophysiology of the role of inflammation in comorbid depression and HIV is poorly understood.

  1. Among depressed HIV-infected Ugandans, determine if the resolution of depression at 26 weeks of HIV therapy is improved with group psychotherapy.
  2. In the same population determine if persistent depression is associated with higher levels of innate inflammation. Also, compare baseline and follow up inflammation among depressed compared to non-depressed control group.
  3. Evaluate if viral suppression levels at 26 weeks are improved by group psychotherapy.

Condition HIV, HIV positive, HIV infection, Endogenous depression, Depression, AIDS Vaccines, Depressed, HIV Infections, depressive disorder, human immunodeficiency virus, hiv disease, HIV Vaccine, hiv vaccines, depressed mood, miserable, depressive disorders
Treatment Group Pyschotherapy, Depression Standard of Care, HIV Standard of Care
Clinical Study IdentifierNCT04286282
SponsorUniversity of Minnesota
Last Modified on31 July 2021


Yes No Not Sure

Inclusion Criteria

For the depressed patient arm
Newly-presenting clinic patients (<3 months)
Mild to Moderately-Severe Depressive Symptoms with PHQ-9 score >5 but <20
Not suicidal (PHQ-9 question 9 score >2)
Not receiving antiretroviral therapy (ART) at screening
Outpatient, not requiring hospitalization
For the non-depressed patient arm
Newly-presenting clinic patients (<3 months)
Not suicidal (PHQ-9 question 9 score >2)
Not receiving antiretroviral therapy (ART) at screening
Outpatient, not requiring hospitalization

Exclusion Criteria

No additional exclusion criteria
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