Efficacy and Safety of Duloxetine in Chinese Solid Tumor Patients With Taxanes-induced Painful Peripheral Neuropathy

  • STATUS
    Recruiting
  • End date
    Jan 1, 2024
  • participants needed
    100
  • sponsor
    Yan Yang, MD, Ph.D
Updated on 30 August 2021
analgesics
opioid

Summary

The study is to evaluate the efficacy and safety of duloxetine in Chinese solid tumor patients with taxanes-induced painful peripheral neuropathy. Duloxetine will be given to patients who have grade 1 or higher sensory neuropathy according to the NCI Common Terminology Criteria for Adverse Events (CTCAE) version 5.0 and at least 4 on a scale of 0 to 10 points, representing average chemotherapy-induced pain, after taxanes treatment. Patient-reported pain severity, functional interference, emotion condition and quality of Life will be assessed weekly using corresponding scales. Blood samples will be collected from each enrolled subjects before the start of treatment, and the potential biomarkers in predicting duloxetine efficacy or safety will be explored by genomic profiling.

Details
Condition Pain (Pediatric), Solid Neoplasm, Chemotherapy Induced Peripheral Neuropathy, Pain, Solid Tumour, ache, Acute Pain Service, Solid Tumor, Post-Surgical Pain, Solid Tumors
Treatment Duloxetine
Clinical Study IdentifierNCT04970121
SponsorYan Yang, MD, Ph.D
Last Modified on30 August 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients must sign an informed consent form (ICF) voluntarily and be able to understand and comply with the requirements of the study
Patients must be 18 to 75 years of age (including cut-offs) on the date of signing the informed consent form, regardless of gender
Patients must be diagnosed with malignant solid tumors by pathological histology or cytology in the central laboratory or study center
Patients must received treatment with a chemotherapy regimen containing taxanes
Patients must have grade 1 sensory chemotherapy-induced peripheral neuropathy (CIPN) with NRS 4/10 according to the NCI Common Toxicity Criteria for Adverse Events (CTCAE) v.5.0 grading scale
Eastern Cooperative Oncology Group performance status (ECOG PS): 0-2
Expected survival of 3 months
Screening values at screening meet the following requirements: (no blood components, cell growth factors, leukocyte-lifting drugs, platelet-lifting drugs, anemia-correcting drugs, etc. are allowed within 14 days prior to obtaining laboratory tests); Complete blood count: neutrophil count (ANC) 1.5 109/L, platelet count (PLT) 90 109/L, hemoglobin (Hb) 90 g/L; Liver function: glutamic aminotransferase (AST), alanine aminotransferase (ALT) and total serum bilirubin (TBIL) 2 times the upper limit of normal range (ULN) Renal function: serum creatinine (Cr) ULN or creatinine clearance (CCr) 80 mL/min (applying the standard Cockcroft -Gault formula)
Female patients who are non-lactating and must have a negative pregnancy test result
Patients of childbearing potential must agree to use effective contraception for at least 30 days after signing the informed consent to the last dose
Note: Concomitant use of selected analgesics (e.g., opioids, acetaminophen
aspirin, and other NSAIDs) is permitted, but only patients receiving a stable
dose during the two weeks prior to enrollment may participate

Exclusion Criteria

Patients with known hypersensitivity to duloxetine or any of the inactive ingredients in the product
Patients on other concomitant medications known to affect 5-hydroxytryptamine (5-HT) levels
Patients who must take monoamine oxidase inhibitors for antidepressant treatment
Patients with the presence of active brain or meningeal metastases
Patients with the presence of uncontrolled closed-angle glaucoma
Patients with the presence of neuropathy caused by any type of nerve compression
The presence of mental illness, epilepsy, mania, suicidal depression, dementia or alcohol or drug abuse that may have an impact on compliance with trial requirements
The presence of comorbid cardiovascular disease, including but not limited to: (1) New York Heart Association (NYHA) criteria grade 2 heart failure; (2) severe/unstable angina pectoris; (3) myocardial infarction or cerebrovascular accident within 6 months prior to first dose; (4) atrial fibrillation and supraventricular or ventricular arrhythmias requiring treatment; (5) pre-existing symptomatic superior vena cava syndrome; (6) corrected QT interval (QTc) > 450 ms (men); QTc > 470 ms (women); (7) hypertensive disease not controlled by antihypertensive medication: systolic blood pressure 140 mmHg or diastolic blood pressure 90 mmHg
Patients with other medical history or evidence of disease that has the potential to confound trial results are excluded from the study
Patients are excluded from the study if investigator/sponsor believes that participation in the study is not in the subject's best interest
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