Serum Levels of Adipocytokines in Children With Febrile Seizures: A Cross-Sectional Study at Sohag University Hospital

    Not Recruiting
  • participants needed
  • sponsor
    Sohag University
Updated on 27 November 2022
Accepts healthy volunteers


Febrile seizure (FS) is a common neurological condition in children, affecting 2 - 14% of children. FS is defined as seizures occurring in a child aged from six months to five years that is accompanied by a fever (≥38°C) without central nervous system infection. FS is classified into simple febrile seizure (SFS) and complex febrile seizure (CFS). SFS accounts for 70-75% of FS cases and is characterized by being generalized, duration of less than 15 minutes, occurs once in 24 hours, and no previous neurologic problems. We aim to investigate serum levels of adipocytokines, specifically leptin, adiponectin, and IL-6, in children with FS.


The study will include three groups of children (100 for each): children with febrile seizures (group 1), febrile children without seizures (group 2), and healthy control children (group 3). Children included in this study will undergo:

  • Thorough medical history taking: including age, gender, and seizure details for children with febrile seizures (e.g., type, duration, recurrence).
  • Physical examination: including vital signs (particularly temperature) and comprehensive neurological examination).
  • Laboratory investigations:
  • Routine investigations: complete blood count, C-reactive protein, blood glucose, serum electrolytes (sodium, potassium, calcium, and magnesium), liver and kidney function tests.
  • Serum leptin, adiponectin, and IL6: venous blood samples (3 ml) will be obtained from children with FS (within 3 hours of seizures) as well as the two control groups. Serum will be obtained by centrifugation at 3,500 rpm for 5 min at 4 ℃. The serum will be immediately separated and stored at -70 ℃. Serum leptin, adiponectin, and IL6 will be assessed through enzyme-linked immunosorbent assay (ELISA) kits according to the manufacturer's instructions.

Condition Febrile Seizure
Treatment Serum Levels of Adipocytokines
Clinical Study IdentifierNCT04967066
SponsorSohag University
Last Modified on27 November 2022

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