Efficacy of G-CSF-Priming in Elderly AML Patients

  • participants needed
  • sponsor
    Johann Wolfgang Goethe University Hospitals
Updated on 22 January 2022
granulocyte colony stimulating factor
cell transplantation
consolidation therapy
secondary acute myeloid leukemia
neoadjuvant therapy
colony stimulating factor


Aim of the study is to compare the efficacy of intensive induction therapy with Cytarabine, Idarubicin and Etoposide (IdAV) given in parallel with (G-CSF priming) and followed by G-CSF versus the same IdAV chemotherapy only followed by G-CSF (without priming) in elderly patients with de novo AML, secondary AML and advanced MDS. Moreover, the ability to mobilize sufficient numbers of peripheral blood stem cells (PBSC) for autologous PBSC transplantation after consolidation therapy with dose-reduced FLAG-Ida chemotherapy followed by G-CSF will be evaluated.

Condition Acute Myeloid Leukemia
Treatment G-CSF, Stem cell transplantation, cytarabine, etoposide, Fludarabine, Idarubicin, Stem cell apheresis
Clinical Study IdentifierNCT00199147
SponsorJohann Wolfgang Goethe University Hospitals
Last Modified on22 January 2022

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