Hydroxychloroquine in Prevention of Preeclampsia

  • End date
    Jun 1, 2022
  • participants needed
  • sponsor
    Assiut University
Updated on 29 July 2021


Pre-eclampsia complicates up to 8% of pregnancies and is a major contributor to maternal mortality and morbidity The only effective treatment is delivery, which leads to significant neonatal morbidity and mortality if carried out preterm, especially when the disease occurs early in pregnancy. Vascular endothelial dysfunction and immunological impairment are associated with preeclampsia. To date, there is no effective or optimal therapeutic approach for these conditions. Hydroxychloroquine has endothelial protective action via ant diabetic, lipid lowering, antioxidant effects or direct endothelial protection. Hydroxychloroquine is an antimalarial and immunomodulatory agent. In pregnancy, hydroxychloroquine is prescribed for inflammatory conditions associated with adverse perinatal outcomes such as systemic lupus erythematosus, antiphospholipid syndrome and placental inflammatory lesions such as chronic histiocytic intervillositis, hydroxychloroquine has therapeutic potential to improve placental function in pregnancies associated with heightened inflammation.

Condition Hydroxychloroquine
Treatment Placebo, Folic acid, hydroxychloroquine, Low-dose aspirin
Clinical Study IdentifierNCT04755322
SponsorAssiut University
Last Modified on29 July 2021


Yes No Not Sure

Inclusion Criteria

Pregnant women in 1st 6 weeks gestation
Women willing to participate

Exclusion Criteria

Known contraindication to treatment by Hydroxychloroquine (
Patients already using Hydroxychloroquine
Impossible to follow-up
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