Sertraline Combined With Fluvoxamine in the Treatment of Refractory Obsessive-compulsive Disorder

  • End date
    Dec 31, 2024
  • participants needed
  • sponsor
    Second Affiliated Hospital, School of Medicine, Zhejiang University
Updated on 25 July 2021


To verify that sertraline combined with fluvoxamine is superior to sertraline combined with aripiprazole


To verify that sertraline combined with fluvoxamine is superior to sertraline combined with aripiprazole, and to observe the indicators of improving patients' cognitive function and adverse drug reactions, so as to provide evidence-based evidence for supplementing the treatment guidelines for obsessive-compulsive disorder

Condition obsessive compulsive disorder, Osteochondritis Dissecans, Obsessive-Compulsive Disorder
Treatment Sertraline, sertraline fluvoxamine
Clinical Study IdentifierNCT04963257
SponsorSecond Affiliated Hospital, School of Medicine, Zhejiang University
Last Modified on25 July 2021


Yes No Not Sure

Inclusion Criteria

The Diagnostic criteria of OCD in the Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM-V), as well as the definition of refractory OCD, are as follows: failure to respond to oral treatment with at least two effective doses of antidepressants, including: Fluoxetine (20mg/ d), fluvoxamine (200mg/d), sertraline (150mg/d), and paroxetine ( 40mg/d) were all treated for at least 12 weeks. The Yale-Brown compulsive scale (Y-BOCS) score decreased by < 35%
The total score of Yale- Brown compulsion scale (Y-BOCS) 16 points. (3)age 12 ~ 45 years

Exclusion Criteria

Exclusion of severe organic brain disease
Severe physical illness
Other mental disorders such as tics, disruptive disorders, eating disorders and autism spectrum disorders
Pediatric streptococcal infection causedby autoimmune neuropsychiatric disease (PANDAS)
Alcohol and drug dependence; Angle-closure glaucoma
Suicidal tendencies
Previous history of drug allergies related to research
Pregnant and lactating women
Clear my responses

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