Impact of SFV of Proximal Colon on ADR

  • STATUS
    Recruiting
  • End date
    Dec 23, 2023
  • participants needed
    910
  • sponsor
    Zhu Xiaojia
Updated on 23 July 2021

Summary

To evaluate the impact of second forward view examination of the proximal colon on adenoma detection rate Inclusion criteriaPatients 18 years of age undergoing screening, follow-up monitoring, and diagnostic colonoscopy Exclusion criteriaCecal intubation failed. Have a history of colorectal surgery. Insufficient bowel preparation, Boston Bowel Preparation Score (BBPS) <6 points. Inflammatory bowel disease or intestinal tuberculosis. Familial polyp syndrome. Recovery of polyp specimens failed, and no histopathological data. Patients with coagulation dysfunction.

Patients 18 years of age who came to our hospital's Digestive Endoscopy Center for screening, follow-up monitoring and diagnosis of colonoscopy. After successfully insert the cecum, colonoscope withdrawal to the splenic flexure, all polyps found during the withdrawal process were resection,then they were randomized to standard withdrawal colonoscopy or second forward view according to the random number table (1:1) to perform.

Description

Background

Colonoscopy can reduce the incidence and mortality rates of colorectal cancer, and the reduction in distal colon cancer is more pronounced than proximal colon cancer. Compared with CRC found on screening, interphase CRC is more likely to occur in the proximal colon above the splenic flexure. Adenoma detection rate (ADR) is an important quality indicator of colonoscopy. Compared with ADR>20%the incidence of interphase CRC is 10 times higher for endoscopists with ADR<20%. For every 1% increase in ADR, the risk of interphase CRC can be reduced by 3%, and fatal interphase CRC can be reduced by 5%. It is reported in the literature that the second forward view examination of the right colon (cecum, ascending colon, liver flexure) can significantly improve the right colon ADR, however, there is no report on the impact of second forward view examination of the proximal colon ADR (cecum, ascending colon, liver flexure, and transverse colon).

Objective

To evaluate the impact of second forward view examination of the proximal colon on adenoma detection rate Inclusion criteria Patients 18 years of age undergoing screening, follow-up monitoring, and diagnostic colonoscopy Exclusion criteria

Cecal intubation failed. Have a history of colorectal surgery. Insufficient bowel preparation, Boston Bowel Preparation Score (BBPS) <6 points. Inflammatory bowel disease or intestinal tuberculosis. Familial polyp syndrome. Recovery of polyp specimens failed, and no histopathological data. Patients with coagulation dysfunction.

Methods

Patients 18 years of age who came to our hospital's Digestive Endoscopy Center for screening, follow-up monitoring and diagnosis of colonoscopy. After successfully insert the cecum, colonoscope withdrawal to the splenic flexure, all polyps found during the withdrawal process were resection,then they were randomized to standard withdrawal colonoscopy or second forward view according to the random number table (1:1) to perform.

Primary Outcome:

proximal colon adenoma detection rateproportion of patients with proximal colon adenoma found in all colonoscopy patients Secondary Outcome total adenoma detection rateproportion of patients with colonic adenoma found in all colonoscopy patients Cecal insertion time: the time elapsed from introducing the colonoscope into the anus until intubation of the cecum.

proximal colon withdrawal time: observation time of proximal colon total withdrawal time:the time measured from when the colonoscope reaches the cecum to the time the scope is withdrawn from the anus in the absence of polyp removal BBPSBoston bowel preparation score

Research design Patients 18 years of age who came to our hospital's Digestive Endoscopy Center for screening, follow-up monitoring and diagnosis of colonoscopy. After successfully insert the cecum, colonoscope withdrawal to the splenic flexure, all polyps found during the withdrawal process were resection,then they were randomized to standard withdrawal colonoscopy or second forward view according to the random number table (1:1) to perform. Patients in the second forward view (SFV) group were inserted into the cecum again , colonoscope withdrawal to the splenic flexure, and the newly discovered polyps in the second forward view were also resection. Patients in the standard withdrawal colonoscopy withdraw the scope from the splenic flexure until exiting the anus,observe, if polyps are found, undergo endoscopic resection.

The assistant is responsible for recording the time.Cecal insertion time refers to the time elapsed from introducing the colonoscope into the anus until intubation of the cecum. Proximal colon withdrawal time refers to the observation time of proximal colon. And the total withdrawal time refers to the time measured from when the colonoscope reaches the cecum to the time the scope is withdrawn from the anus in the absence of polyp removal. Record BBPS, the number, location, size, Paris type and postoperative pathology of polyps.

Details
Condition Adenoma Detection Rate
Treatment second forward view
Clinical Study IdentifierNCT04963010
SponsorZhu Xiaojia
Last Modified on23 July 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients 18 years of age undergoing screening, follow-up
monitoring, and diagnostic colonoscopy -

Exclusion Criteria

Cecal intubation failed. Have a history of colorectal
surgery. Insufficient bowel preparation, Boston Bowel Preparation Score (BBPS)
<6 points. Inflammatory bowel disease or intestinal tuberculosis. Familial
polyp syndrome. Recovery of polyp specimens failed, and no histopathological
data. Patients with coagulation dysfunction
\-
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