Comparing Smoking Cessation Interventions Among Underserved Patients Referred for Lung Cancer Screening

  • End date
    Dec 19, 2024
  • participants needed
  • sponsor
    University of Pennsylvania
Updated on 19 July 2021
nicotine replacement
lung cancer screening


To compare the effectiveness of four interventions to promote sustained, biochemically confirmed smoking abstinence for 6 months among underserved smokers referred for lung cancer screening at four large U.S. health systems.


We will conduct a 4-arm randomized trial comparing 4 interventions to promote sustained, biochemically confirmed smoking abstinence for 6 months among smokers in underserved demographic groups. The 3,200 participants to be enrolled will be current smokers who are Black, Hispanic, and/or have low socioeconomic status (defined as household income <200% of the federal poverty line or a high school education or less) or rural residence who are referred for low-dose computed tomography (LDCT) screening at 4 large health systems. All adult patients with LDCT orders will be further screened for eligibility. Eligible patients will enroll and complete the study using the NIH-funded Way to Health online research portal. The primary outcome will be biochemically confirmed, sustained abstinence from smoking tobacco for 6 months following participants' selected quit dates. Relapse rates will be tracked at 12 months.

Condition Smoking Cessation, smoking cessation therapy
Treatment Financial incentives, mobile health application, Removal of Financial Barriers
Clinical Study IdentifierNCT04798664
SponsorUniversity of Pennsylvania
Last Modified on19 July 2021


Yes No Not Sure

Inclusion Criteria

Current smoker ( 1 cigarettes per day, not including e-cigarettes)
Has a low-dose computed tomography (LDCT) scan ordered by their physician
Underserved, defined as one or more of the following: (a) Black, (b) Hispanic, (c) rural residence, or (d) low socioeconomic status (Defined as one or both of: high-school education or less, or household income <200% of the federal poverty line)
Able to receive study invitation and screening, by virtue of showing up to a radiology location affiliated with a participating health system for the LDCT, or having a valid email address or telephone number on file with the health system
Access to a cell phone with text messaging or the internet
Aged 18 years or older

Exclusion Criteria

No cell phone
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