A Combined Multidomain Intervention to Prevent Cognitive Decline Associated With Cardiovascular Risk Factors.

  • End date
    Sep 30, 2024
  • participants needed
  • sponsor
    Louis Bherer
Updated on 6 October 2021
Accepts healthy volunteers


The ACTIONcardioRisk trial is designed to investigate the effect of aerobic and progressive resistance training exercises combined with cognitive training, on neurocognitive functioning of sedentary older adults with and without cardiovascular risk factors.


The proportion of older adults is on the rise in Canada, with the fastest growth recorded among those seventy years of age or older. The prevalence of cardiovascular risk factors (CVRF) such as diabetes, hypertension, and high cholesterol increases drastically with age. Individuals with CVRF often show impaired cognition, such as attention and memory deficits. In healthy older adults, exercise training and cognitive stimulation can help enhance cognitive performances. More precisely, combined intervention, including physical and cognitive training, has shown beneficial effects on cognition in older adults without cognitive impairment and with mild cognitive impairment. However, the effect of such programs on cognition in individuals with CVRF is not well documented. This project compares the effect of a physical exercise program, including aerobic and resistance training, alone or combined with cognitive training on cognitive performances and brain imaging outcomes in individuals with CVRF and healthy controls.

Condition Aging, Senility, Cardiovascular Risk Factor
Treatment Cognitive training, Stretching and toning, Aerobic and resistance exercises
Clinical Study IdentifierNCT04962061
SponsorLouis Bherer
Last Modified on6 October 2021


Yes No Not Sure

Inclusion Criteria

Adult aged 60 and older
Normal or corrected vision and normal hearing for their age range
No cognitive impairment (Mini-Mental State Examination - MMSE 25)
Inactive (< 150 min of physical activity per week)

Exclusion Criteria

MMSE 24 or diagnosis of dementia
Uncontrolled psychological / psychiatric condition within the past 6 months
Neurological disease
Severe exercise intolerance
Respiratory disease (e.g., asthma, COPD)
Excessive alcohol consumption (> 15 drinks/week)
Documented cerebral, peripheral or coronary atherosclerotic disease
Chronic systolic or diastolic heart failure
Symptomatic aortic stenosis
Atrial fibrillation
Automatic implantable defibrillator or permanent pacemaker
Malignant exertional arrhythmias
Non-cardiopulmonary limitation to exercise (e.g., arthritis)
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact


Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note