A Combined Multidomain Intervention to Prevent Cognitive Decline Associated With Cardiovascular Risk Factors.

  • STATUS
    Recruiting
  • End date
    Sep 30, 2024
  • participants needed
    318
  • sponsor
    Louis Bherer
Updated on 21 July 2021
Investigator
Louis Bherer, PhD
Primary Contact
Preventive medicine and physical activity centre (centre EPIC), Montreal Heart Institute (4.7 mi away) Contact

Summary

The ACTIONcardioRisk trial is designed to investigate the effect of aerobic and progressive resistance training exercises combined with cognitive training, on neurocognitive functioning of sedentary older adults with and without cardiovascular risk factors.

Description

The proportion of older adults is on the rise in Canada, with the fastest growth recorded among those seventy years of age or older. The prevalence of cardiovascular risk factors (CVRF) such as diabetes, hypertension, and high cholesterol increases drastically with age. Individuals with CVRF often show impaired cognition, such as attention and memory deficits. In healthy older adults, exercise training and cognitive stimulation can help enhance cognitive performances. More precisely, combined intervention, including physical and cognitive training, has shown beneficial effects on cognition in older adults without cognitive impairment and with mild cognitive impairment. However, the effect of such programs on cognition in individuals with CVRF is not well documented. This project compares the effect of a physical exercise program, including aerobic and resistance training, alone or combined with cognitive training on cognitive performances and brain imaging outcomes in individuals with CVRF and healthy controls.

Details
Condition Senility, Cardiovascular Risk Factor
Treatment Cognitive training, Stretching and toning, Aerobic and resistance exercises
Clinical Study IdentifierNCT04962061
SponsorLouis Bherer
Last Modified on21 July 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Adult aged 60 and older
Normal or corrected vision and normal hearing for their age range
No cognitive impairment (Mini-Mental State Examination - MMSE 25)
Inactive (< 150 min of physical activity per week)

Exclusion Criteria

MMSE 24 or diagnosis of dementia
Uncontrolled psychological / psychiatric condition within the past 6 months
Neurological disease
Severe exercise intolerance
Respiratory disease (e.g., asthma, COPD)
Excessive alcohol consumption (> 15 drinks/week)
Documented cerebral, peripheral or coronary atherosclerotic disease
Chronic systolic or diastolic heart failure
Symptomatic aortic stenosis
Atrial fibrillation
Automatic implantable defibrillator or permanent pacemaker
Malignant exertional arrhythmias
Non-cardiopulmonary limitation to exercise (e.g., arthritis)
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