Intraoperative Mechanical Ventilation and Postoperative Pulmonary Complications After On-pump Cardiac Surgery in High-risk Patients

  • End date
    Jul 8, 2024
  • participants needed
  • sponsor
    Rennes University Hospital
Updated on 22 July 2021


Controversies remain concerning the best intraoperative mechanical ventilation regimen for major cardiac surgery. While the use of intra operative low tidal volumes is now standard practice, the optimal level of positive end-expiratory pressure (PEEP) and the use of recruitment maneuvers (RM) remain controversial. The aim of this study is to compare two regimens of intraoperative mechanical ventilation on postoperative outcomes in cardiac surgery patients at risk of postoperative pulmonary complications


In this randomized controlled trial, cardiac surgery patients at risk of postoperative pulmonary complications will be assigned to intraoperative ventilation with high PEEP and RM or intraoperative mechanical ventilation with low PEEP and without RM. The primary endpoint will be a composite endpoint including major postoperative complications within the first postoperative week and death within the 28 days after surgery

Condition Postoperative Pulmonary Complications
Treatment Control group, Intervention group_MRA
Clinical Study IdentifierNCT04408495
SponsorRennes University Hospital
Last Modified on22 July 2021


Yes No Not Sure

Inclusion Criteria

Patients older than 18 years-old
Evaluated before cardiopulmonary bypass for any cardiac surgical procedure (e.g. coronary artery bypass grafting, valve, aorta, or combined procedures)
With a pulmonary risk score 2
Who gave written informed consent
affiliated to a social security system

Exclusion Criteria

BMI > 40kg/m2
Left Ventricular Ejection Fraction < 35%
Preoperative shock
Aortic surgery with planned circulatory arrest
Minimally invasive cardiac surgery
Emergency surgery with patient unable to give written informed consent
Heart transplantation
Mechanical circulatory support surgery
Pregnant or lactating women
Adults legally protected (under judicial protection, guardianship, or supervision), persons deprived of their liberty
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