Pharmacokinetic and Pharmacodynamic Study of S-1 in Patients With Digestive Organ Cancer
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- STATUS
- Recruiting
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- sponsor
- Hamamatsu University
Summary
S-1 is a novel oral fluorouracil antitumor drug that consists of tegafur which is a prodrug of 5-fluorouracil (5-FU); 5-chloro-2,4-dihydropyridine (CDHP), which inhibits dihydropyrimidine dehydrogenase (DPD) activity; and potassium oxonate (Oxo), which reduces gastrointestinal toxicity. 5-FU is metabolized by CYP2A6 and DPD. In this study, the researchers investigate the influences of differences in activities of CYP2A6 and DPD on pharmacokinetics and pharmacodynamics of S-1 and clinical outcomes in digestive organ cancer patients treated with S-1.
Details
| Condition | Pancreatic Cancer, Esophageal Cancer, Malignant neoplasm of colon, Gastric Cancer |
|---|---|
| Treatment | S-1 |
| Clinical Study Identifier | NCT00197431 |
| Sponsor | Hamamatsu University |
| Last Modified on | 7 November 2020 |
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