Pharmacokinetic and Pharmacodynamic Study of S-1 in Patients With Digestive Organ Cancer

  • STATUS
    Recruiting
  • sponsor
    Hamamatsu University
Updated on 22 January 2022
cancer
fluorouracil
potassium
tegafur
gimeracil

Summary

S-1 is a novel oral fluorouracil antitumor drug that consists of tegafur which is a prodrug of 5-fluorouracil (5-FU); 5-chloro-2,4-dihydropyridine (CDHP), which inhibits dihydropyrimidine dehydrogenase (DPD) activity; and potassium oxonate (Oxo), which reduces gastrointestinal toxicity. 5-FU is metabolized by CYP2A6 and DPD. In this study, the researchers investigate the influences of differences in activities of CYP2A6 and DPD on pharmacokinetics and pharmacodynamics of S-1 and clinical outcomes in digestive organ cancer patients treated with S-1.

Details
Condition Gastric Cancer, Esophageal Cancer, Pancreatic Cancer, Colon Cancer
Treatment S-1
Clinical Study IdentifierNCT00197431
SponsorHamamatsu University
Last Modified on22 January 2022

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