Meniscus Regeneration After Meniscectomy and Its Clinical Significance

  • End date
    Dec 20, 2022
  • participants needed
  • sponsor
    Peking University Third Hospital
Updated on 20 July 2021


Meniscus injury is common in sports-active population, and partial or total meniscectomy is standard surgery for meniscal tear. Meniscus plays an important role in load transferring, shock absorbing, knee joint stabilizing and chondral protection. Plenty of studies indicate that meniscus-deficiency increases the risk of OA and cause long-term poor outcomes.

Spontaneous human meniscus regeneration is rarely reported and whether regenerated meniscus is chondral-protective and can prevent OA progression remain unknown. During our clinical practice, we have encountered many cases with complete meniscal regeneration under arthroscopy. In this study, we will include all the patients who receiving meniscectomy and ACL reconstruction and knee arthroscopy 2 years after primary surgery. Patients demographic characters will be reviewed. The resected meniscus in the primary surgery and biopsied regenerated meniscus will be analyzed by histological and immunohistochemical method and their ultrastructure will be observed by electron microscope. Patients will be followed at 2-, 5- and 10-year after the primary surgery and the cartilage degeneration and OA progression will be assessed.

Condition Regeneration, Meniscal Tear, Meniscus Tear, torn meniscus
Treatment Arthroscopy
Clinical Study IdentifierNCT04959292
SponsorPeking University Third Hospital
Last Modified on20 July 2021


Yes No Not Sure

Inclusion Criteria

Patients intending to undergo single-knee ACL reconstruction at our Institute of Sports Medicine
The age of 18 ~ 50 years old at the time of operation
Both men and women
BMI < 24\
Complete or partial meniscectomy was performed at the same time as ACL reconstruction
Patients willing to undergo a second arthroscopic exploration 2 years postoperatively and to take the portal screws used to fix the ligaments during the initial surgery
Patients with preserved meniscus video during ACL reconstruction
The degree of knee osteoarthritis (KOA) at the time of operation was < of Kellgren Laurence level

Exclusion Criteria

Patients with severe knee cartilage injury
Patients with KOAKL at the time of operation
The patients cannot be followed up
Patients who refused the second arthroscopy and the removal of the internal fixation portal screw at the time of surgery
Patients with rheumatoid arthritis or other arthritis
Patients with other systemic diseases who take oral anti-inflammatory analgesics for years
Patients with multiple injections of drugs in the joint due to various reasons
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