A Clinical Studyf of SHR-1701 or Placebo in Combination With BP102 and XELOX in the First-line Treatment of mCRC

  • STATUS
    Recruiting
  • End date
    Nov 6, 2024
  • participants needed
    439
  • sponsor
    Suzhou Suncadia Biopharmaceuticals Co., Ltd.
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Updated on 21 July 2021
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Summary

This is a two-arm, randomized, double-blinded, multicenter phase II/III clinical study to evaluate the safety and clinical efficacy of SHR-1701 or placebo in combination with BP102 (biosimilar to bevacizumab) and XELOX in first-line treatment of patients with mCRC.

Details
Condition Metastatic Colorectal Cancer
Treatment SHR-1701、 BP102 、XELOX, placebo、 BP102、 XELOX
Clinical Study IdentifierNCT04856787
SponsorSuzhou Suncadia Biopharmaceuticals Co., Ltd.
Last Modified on21 July 2021

Eligibility

 Yes No Not Sure

Inclusion Criteria

Patients with unresectable recurrent or metastatic adenocarcinoma of the colon or rectum confirmed histologically
For subjects who have not previously received any systemic antitumor therapy and who have previously received neoadjuvant or adjuvant therapy, the first detection of recurrence or metastasis should be 12 months after the last administration of neoadjuvant or adjuvant therapy
At least 1 measurable lesion according to RECIST V1.1
The vital organs are functioning well
ECOG score is 0 ~ 1
Contraception was initiated from the signing of the informed consent until at least 6 months after the last dosing of the study drug

Exclusion Criteria

Recurrent or metastatic lesions can be treated with radical surgery
Presence of central nervous system or meningeal metastases
Moderate and severe ascites of clinical symptoms;Uncontrolled or moderate or greater pleural effusion or pericardial effusion
Poorly controlled hypertension (systolic blood pressure 140 mmHg and/or diastolic blood pressure 90 mmHg in the case of regular antihypertensive therapy) and prior hypertensive crisis or hypertensive encephalopathy
Severe cardiovascular and cerebrovascular diseases;Have clinical heart symptoms or diseases that are not well controlledSubjects with a history of myocardial infarction or unstable angina pectoris
Subject with current interstitial pneumonia or interstitial lung disease, or with a previous history of interstitial pneumonia or interstitial lung disease requiring hormone therapy
Previous treatment with targeted T cell costimulatory molecules and immune checkpoint inhibitors;Previous treatment with antiepidermal growth factor receptor or any antiangiogenic drug
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